Upfront Xpert MTB/RIF testing on various specimen types for presumptive infant TB cases for early and appropriate treatment initiation.

PloS One
Neeraj RaizadaCatharina Boehme

Abstract

Diagnosis of tuberculosis (TB) in infants is challenging due to non-specific clinical presentations of the disease in this age-group and low sensitivity of widely available TB diagnostic tools, which in turn delays prompt access to TB treatment. Upfront access to Xpert/MTB RIF (Xpert) testing, a highly sensitive and specific rapid diagnostic tool, could potentially address some of these challenges. Under the current project, we assessed the utility and feasibility of applying upfront Xpert for diagnosis of tuberculosis in infants, including for testing of non-sputum specimens. A high throughput lab was established in each of the four project cities, and linked to various health care providers across the city, through rapid specimen transportation and electronic reporting linkages. Free Xpert testing was offered to all infant (<2 years of age) presumptive TB cases (both pulmonary and extra-pulmonary) seeking care at public and private health facilities. A total of 7,994 presumptive infant TB cases were enrolled in the project from April 2014 to October 2016, detecting 465 (5.8%, CI: 5.3-6.4) TB cases. The majority (93.9%; CI: 93.4-94.4) of patient specimens were non-sputum and TB positivity was higher amongst non-sputum specimen...Continue Reading

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Citations

Aug 28, 2020·The Cochrane Database of Systematic Reviews·Alexander W KayAnna M Mandalakas
Jan 16, 2021·The Cochrane Database of Systematic Reviews·Mikashmi KohliKaren R Steingart
Dec 10, 2019·The Indian Journal of Tuberculosis·Sangeeta SharmaV P Myneedu

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Software Mentioned

GeneXpert
- Data Analysis
Xpert
Excel
Epi
R

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