Upgraded nerve growth factor expression induced by low-intensity continuous-wave ultrasound accelerates regeneration of neurotometicly injured sciatic nerve in rats

Ultrasound in Medicine & Biology
Wen-Zhi ChenZhi-Biao Wang

Abstract

Low-intensity ultrasound (LIU) can stimulate injured nerve regeneration but the mechanism is still unclear. We investigated the stimulating effect and its mechanism of continuous-wave LIU on neurotometic injury of sciatic nerve. The right sciatic nerves of 64 adult Wistar rats were first crushed and then exposed (32 rats) or sham-exposed (32 rats) to LIU at the crush site. The LIU had a spatial averaged and temporal averaged intensity of 0.25 W/cm(2) operated at 1.0 MHz for 1 min every other day. At various stages (the second, fourth, sixth and eighth weeks) after LIU exposure, the sciatic nerve function index (SFI), the sensory nerve conduction velocity (SNCV), the expression of nerve growth factor (NGF) and sample histology were studied. It was found that the density of nerve fibers with myelin sheath, SFI, SNCV and NGF expression of the treatment group were higher than that of control group (p < 0.05). It has been determined that LIU treatment can accelerate the regeneration and functional recovery of neurotometic injured sciatic nerve at earlier stages after injury, the upgraded expression of NGF induced by LIU may be the primary mechanism of the acceleration effects.

References

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Citations

Aug 29, 2013·Australasian Physical & Engineering Sciences in Medicine·Fatemeh Zareayan JahromyJalal Izadi Mobarake
Jul 16, 2014·Ultrasound in Medicine & Biology·I-Chi LeeYing-Chih Chang
Feb 19, 2013·Ultrasound in Medicine & Biology·Yaxin HuAlfred C H Yu
Jul 7, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Paul Ryan HaffeyAmitabh Gulati
Jul 12, 2017·Neurological Research·Gladson Ricardo Flor BertoliniRose Meire Costa Brancalhão
Aug 22, 2018·Neural Regeneration Research·Konstantin D BergmeisterLeila Harhaus

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