Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades.

European Urology
Jonathan I EpsteinPhillip M Pierorazio

Abstract

Prior studies assessing the correlation of Gleason score (GS) at needle biopsy and corresponding radical prostatectomy (RP) predated the use of the modified Gleason scoring system and did not factor in tertiary grade patterns. To assess the relation of biopsy and RP grade in the largest study to date. A total of 7643 totally embedded RP and corresponding needle biopsies (2004-2010) were analyzed according to the updated Gleason system. All patients underwent prostate biopsy prior to RP. The relation of upgrading or downgrading to patient and cancer characteristics was compared using the chi-square test, Student t test, and multivariable logistic regression. A total of 36.3% of cases were upgraded from a needle biopsy GS 5-6 to a higher grade at RP (11.2% with GS 6 plus tertiary). Half of the cases had matching GS 3+4=7 at biopsy and RP with an approximately equal number of cases downgraded and upgraded at RP. With biopsy GS 4+3=7, RP GS was almost equally 3+4=7 and 4+3=7. Biopsy GS 8 led to an almost equal distribution between RP GS 4+3=7, 8, and 9-10. A total of 58% of the cases had matching GS 9-10 at biopsy and RP. In multivariable analysis, increasing age (p<0.0001), increasing serum prostate-specific antigen level (p<0.000...Continue Reading

References

Apr 2, 2005·American Journal of Clinical Oncology·Christopher R KingMartha K Terris
Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Mar 27, 2007·Urology·Stephen J FreedlandUNKNOWN SEARCH Database Study Group
Sep 18, 2007·The Journal of Urology·Ofer N GofritArieh L Shalhav
Feb 22, 2008·The Journal of Urology·Samson W Fine, Jonathan I Epstein
Sep 9, 2008·International Journal of Radiation Oncology, Biology, Physics·Katia Ramos Moreira LeiteMiguel Srougi
Dec 24, 2009·Prostate Cancer and Prostatic Diseases·D ColleselliC Schwentner
Mar 20, 2010·Urologia Internationalis·Harri VisapääUlf-Håkan Stenman
Aug 24, 2010·Urology·Kentaro KuroiwaUNKNOWN Clinicopathological Research Group for Localized Prostate Cancer Investigators
Sep 4, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Lars BudäusPierre I Karakiewicz
Sep 8, 2011·BJU International·Niall M CorcoranAnthony J Costello
Oct 22, 2011·The Journal of Urology·Judson D DaviesDaniel A Barocas

❮ Previous
Next ❯

Citations

Jul 19, 2013·International Urology and Nephrology·Anup VoraJonathan Hwang
Jul 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Katharina GruppMaria Christina Tsourlakis
Oct 4, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H Ballentine CarterJonathan I Epstein
Jan 10, 2014·Journal of Clinical Pathology·Kilian M TreurnietTheodorus H Van der Kwast
May 14, 2014·Nature Reviews. Urology·Christian BachAnthony Koupparis
Sep 23, 2014·BioMed Research International·A Marije HooglandGeert J L H van Leenders
Oct 7, 2014·Urology·Jonathan L SilbersteinOliver Sartor
Jul 10, 2014·PloS One·Eduardo LezeCarlos A Mandarim-de-Lacerda
Jan 27, 2016·Der Pathologe·G KristiansenUNKNOWN Graduierungskommittee
Dec 29, 2015·The Journal of Urology·Toshihiro YamamotoLaurence Klotz
Jul 15, 2015·European Urology·Jonathan I EpsteinEric A Klein
Jan 31, 2016·Human Pathology·Evita T SadiminJonathan I Epstein
Nov 6, 2013·Hematology/oncology Clinics of North America·Jonathan L WrightDaniel W Lin
Mar 5, 2013·European Urology·Roderick C N van den BerghHenk G van der Poel
Oct 25, 2012·European Urology·Fadi BrimoJonathan I Epstein
Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Duc FehrJoseph O Deasy
Aug 27, 2015·Asian Journal of Andrology·Ravi KackerAbraham Morgentaler
Nov 14, 2015·Virchows Archiv : an International Journal of Pathology·Sonja D ChenAli Amin
Mar 10, 2016·Diagnostic Pathology·Jennifer Gordetsky, Jonathan Epstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.