UPLC-PDA determination of paeoniflorin in rat plasma following the oral administration of Radix Paeoniae Alba and its effects on rats with collagen-induced arthritis

Experimental and Therapeutic Medicine
Dan WuXi Huang

Abstract

Rheumatoid arthritis (RA) is a chronic disabling autoimmune disease with characteristics of chronic, progressive inflammatory joint synovial damage, which mainly encroaches upon the synovium of the joint. The use of traditional medicine to treat RA slows the development of RA to a certain extent; however, it often has numerous side-effects. Therefore, the focus of RA research is the identification of a new, safe and effective medicine. The aim of the present study was to use an ultra performance liquid chromatography and photo diode array (UPLC-PDA) method to detect the paeoniflorin component in a Radix Paeoniae Alba decoction and in rat plasma following the oral administration of Radix Paeoniae Alba decoction. In addition, the effects of paeoniflorin on collagen-induced arthritis (CIA) in rats were investigated. The results indicate that a UPLC-PDA method for determining the presence of paeoniflorin in the Radix Paeoniae Alba decoction was successfully established. The method was fast, simple, sensitive, precise and valid. Paeoniflorin was shown to be a bioactive component of the Radix Paeoniae Alba decoction that was absorbed into rat plasma. Paeoniflorin significantly improved the disease resistant ability of RA rats and red...Continue Reading

References

Apr 13, 2002·Japanese Journal of Pharmacology·Lih-Chi ChenLing-Ling Yang
Mar 17, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiaoyan ChenDafang Zhong
Mar 28, 2006·Journal of Chromatography. a·Stephen A C Wren, Pierre Tchelitcheff
Aug 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Davy GuillarmeJean-Luc Veuthey
Sep 4, 2007·Journal of Chromatography. a·Dao T-T NguyenJean-Luc Veuthey
Sep 13, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L L ZhangX Y Hu
Oct 31, 2008·Talanta·Lucie NovákováPetr Solich
Nov 5, 2008·The Journal of Clinical Investigation·Fionula M Brennan, Iain B McInnes

❮ Previous
Next ❯

Citations

Apr 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Hao ZhuDan Wu
Mar 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zhihui ZhangZhiwen Wang
Jul 28, 2020·Animal Reproduction·Min Jung ParkBo Sun Joo
Jun 2, 2017·International Journal of Analytical Chemistry·Chuanqi Zhou, Xiaoke Wang
Jun 2, 2018·Journal of Analytical Methods in Chemistry·Ji Hyun JeongSeong Ho Ham
Aug 18, 2018·Experimental and Therapeutic Medicine·Peng-Fei HuLi-Dong Wu
Oct 8, 2019·Journal of Oral Science·Çağla Gül GürkanBurcu Özkan Çetinkaya
Feb 18, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wanying WangLiang Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
X-ray

Software Mentioned

SPSS

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.