UPLC-QTOF/MS-Based Lipidomic Profiling of Liver Qi-Stagnation and Spleen-Deficiency Syndrome in Patients with Hyperlipidemia

Evidence-based Complementary and Alternative Medicine : ECAM
Piao ShenghuaJiao Guo

Abstract

Hyperlipidemia is a common disease caused by abnormal plasma lipid metabolism. Lipidomics is a powerful and efficient technology to study the integration of disease and syndrome of Chinese medicine. This study investigated specific changes in lipid metabolites from hyperlipidemia patients with syndrome of liver qi-stagnation and spleen-deficiency (SLQSD). Lipid profiles in plasma samples from 29 hyperlipidemia patients including 10 SLQSD and 19 non-SLQSD and 26 healthy volunteers (NC) were tested by UPLC-QTOF/MS. PLS-DA analysis and database searching were performed to discover differentiating metabolites. Differences in lipid metabolites between hyperlipidemia and healthy people mainly include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, and ceramides. Hyperlipidemia patients with SLQSD and non-SLQSD could be differentiated by using identified lipid metabolites including phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, triglycerides, diacylglycerols, lysophosphatidylethanolamines, sphingomyelins, lysophosphatidylcholines, and lactosylceramides. There were significant differences of lipid metabolism between between different syndromes of the same disease such as hyperlipidemia w...Continue Reading

References

Sep 30, 2010·Journal of Cellular and Molecular Medicine·Chuan-Li LuJian-Guo Jiang
Sep 15, 2011·Nature Reviews. Molecular Cell Biology·Wouter H Moolenaar, Anastassis Perrakis
Feb 11, 2012·Journal of Ethnopharmacology·Miao JiangKelvin Chan
Aug 1, 2012·PloS One·Melissa N BarberClinton R Bruce
Jan 29, 2013·Critical Reviews in Biochemistry and Molecular Biology·Neale D Ridgway
Jan 1, 2014·Sub-cellular Biochemistry·Shinsuke Hisaka, Toshihiko Osawa
Jun 12, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yue-Tao LiuZhong-Mei Zou
Nov 8, 2014·International Review of Cell and Molecular Biology·Ying-Yong ZhaoRui-Chao Lin
Feb 19, 2015·Biomarkers in Medicine·Ying-Yong ZhaoFeng Wei
Mar 17, 2015·The Journal of Nutritional Biochemistry·Diana N ObandaWilliam T Cefalu
May 1, 2015·Journal of Proteome Research·Simion KreimerAlexander R Ivanov
Jan 14, 2016·Journal of Agricultural and Food Chemistry·Hua MiaoYing-Yong Zhao
Feb 20, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Roxane KhoogarMichael J Wargovich
Apr 5, 2016·Chemico-biological Interactions·Dan-Qian ChenYing-Yong Zhao
Mar 25, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dan-Qian ChenYing-Yong Zhao
Nov 22, 2017·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ming WangYing-Yong Zhao
Feb 10, 2018·Pharmaceutical Biology·Zhenzhen LiuPengyi Hou
Apr 27, 2018·Journal of Pharmaceutical and Biomedical Analysis·Hongyu JiZhimin Du

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Citations

May 1, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiao-Juan LiJia-Xu Chen

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Methods Mentioned

BETA
PCA

Software Mentioned

Excel
Micromass MarkerLynx Applications Manager
SIMCA
SPSS
PLS
DA

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