Upper airway dynamic imaging during tidal breathing in awake and asleep subjects with obstructive sleep apnea and healthy controls

Physiological Reports
Chantal DarquenneAtul Malhotra

Abstract

We used magnetic resonance imaging (MRI) to quantify change in upper airway dimension during tidal breathing in subjects with obstructive sleep apnea (OSA, N = 7) and BMI-matched healthy controls (N = 7) during both wakefulness and natural sleep. Dynamic MR images of the upper airway were obtained on a 1.5 T MR scanner in contiguous 7.5 mm-thick axial slices from the hard palate to the epiglottis along with synchronous MRI-compatible electroencephalogram and nasal/oral flow measurements. The physiologic data were retrospectively scored to identify sleep state, and synchronized with dynamic MR images. For each image, the upper airway was characterized by its area, and linear dimensions (lateral and anterior-posterior). The dynamic behavior of the upper airway was assessed by the maximum change in these parameters over the tidal breath. Mean upper airway caliber was obtained by averaging data over the tidal breath. There was no major difference in the upper airway structure between OSA and controls except for a narrower airway at the low-retropalatal/high-retroglossal level in OSA than in controls. Changes in upper airway size over the tidal breath ((maximum - minimum)/mean) were significantly larger in the OSA than in the contro...Continue Reading

References

Apr 1, 1983·The American Review of Respiratory Disease·P M SurattS C Wilhoit
Apr 1, 1993·Journal of Applied Physiology·R J SchwabE A Hoffman
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·J C Leiter
Nov 1, 1996·Sleep·P CollardD O Rodenstein
Oct 6, 1997·The European Respiratory Journal·S E MartinN J Douglas
Feb 24, 2001·The Annals of Otology, Rhinology, and Laryngology·K IkedaT Takasaka
Apr 20, 2001·The European Respiratory Journal·M A CiscarJ Basterra
Jul 23, 2002·Lancet·Atul Malhotra, David P White
May 15, 2003·American Journal of Respiratory and Critical Care Medicine·Richard J SchwabAllan I Pack
Sep 6, 2003·Otolaryngologic Clinics of North America·Chris Yang, B Tucker Woodson
Feb 6, 2008·Proceedings of the American Thoracic Society·Danny J Eckert, Atul Malhotra
Jun 6, 2008·The Laryngoscope·Gregory C BarkdullTerence M Davidson
Nov 20, 2009·Acta Oto-laryngologica·Li-Pang ChuangYing-Huang Tsai
Feb 13, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark E WagshulRaanan Arens
Apr 17, 2013·American Journal of Epidemiology·Paul E PeppardKhin Mae Hla

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Citations

Oct 30, 2018·Annals of the American Thoracic Society·Roberta M KatoSally L Davidson Ward
May 14, 2019·Frontiers in Neuroscience·Satvinder Kaur, Clifford B Saper
Sep 13, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Monique Suarez-GironJosep M Montserrat
Jul 10, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Keith VolnerMacario Camacho

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Software Mentioned

Sleepware
MATLAB
Sleepware G3
Brain Vision Analyzer
Amira

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