Upper-airway dysbiosis related to frequent sweets consumption increases the risk of asthma in children with chronic rhinosinusitis.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Paweł MajakPiotr Kuna

Abstract

Innate immunity response to local dysbiosis seems to be one of the most important immunologic backgrounds of chronic rhinosinusitis (CRS) and concomitant asthma. We aimed to assess clinical determinants of upper-airway dysbiosis and its effect on nasal inflammatory profile and asthma risk in young children with CRS. We recruited one hundred and thirty-three children, aged 4-8 years with doctor-diagnosed CRS with or without asthma. The following procedures were performed in all participants: face-to-face standardized Sinus and Nasal Quality of Life questionnaire, skin prick test, taste perception testing, nasopharynx swab, and sampling of the nasal mucosa. Upper-airway dysbiosis was defined separately by asthma-specific microbiome composition and reduced biodiversity. Multivariate methods were used to define the risk factors for asthma and upper-airway dysbiosis and their specific inflammatory profile of nasal mucosa. The asthma-specific upper-airway microbiome composition reflected by the decreased ratio of Patescibacteria/Actinobacteria independently of atopy increased the risk of asthma (OR:8.32; 95%CI: 2.93-23.6). This asthma-specific microbiome composition was associated with ≥ 7/week sweet consumption (OR:2.64; 95%C:1.11-6...Continue Reading

References

Feb 10, 1995·Analytical Biochemistry·P Chomczynski, K Mackey
Jan 16, 2013·Genome Biology·Yanjiao ZhouGeorge M Weinstock
Sep 1, 2016·The Journal of Allergy and Clinical Immunology·Martin DepnerAntje Legatzki
Sep 24, 2016·American Journal of Rhinology & Allergy·Benjamin M Hariri, Noam A Cohen
Jan 7, 2017·Gut Microbes·Kristina B MartinezEugene B Chang
Jul 15, 2017·Nutrients·Shakeela N JayasingheBernhard H Breier
Jan 10, 2018·The Journal of Allergy and Clinical Immunology·Patrick MalliaJohn S Tregoning
Jul 1, 2018·International Journal of Pediatric Otorhinolaryngology·Jonathan S NiZachary M Soler
Dec 14, 2018·Current Opinion in Allergy and Clinical Immunology·Jivianne T LeeVijay Ramakrishnan
Mar 7, 2019·Scientific Reports·Camilla CattaneoElla Pagliarini
Mar 16, 2019·American Journal of Respiratory and Critical Care Medicine·Steven L TaylorJodie L Simpson
Mar 29, 2019·Pediatric Pulmonology·Diana MalaebPascale Salameh
Jun 16, 2019·The Journal of Allergy and Clinical Immunology·Kathryn McCauleyUNKNOWN National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium
Aug 31, 2019·Nutrients·Ryan M Carey, Robert J Lee
Oct 22, 2019·Immunology·Daping YangYoucun Qian
Nov 9, 2019·BMC Biology·Christina KumpitschChristine Moissl-Eichinger
Dec 6, 2019·Nutrients·Chelsea L KrachtAmanda E Staiano
Dec 18, 2019·Nature Communications·Yanjiao ZhouAvraham Beigelman
Feb 6, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Anna Maria ZicariMarzia Duse
Feb 23, 2020·Immunity·Weronika BarcikB Brett Finlay
Aug 28, 2020·International Forum of Allergy & Rhinology·Cailu LinNoam A Cohen

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Citations

Jan 26, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Angelica TiotiuFulvio Braido

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