PMID: 9637637Jun 24, 1998Paper

Upper airway reflexes during a combination of propofol and fentanyl anesthesia

Anesthesiology
Y TagaitoT Nishino

Abstract

The effects of intravenous anesthetics on airway protective reflexes have not been fully explored. The purpose of the present study was to characterize respiratory and laryngeal responses to laryngeal irritation during increasing doses of fentanyl under propofol anesthesia. Twenty-two female patients anesthetized with propofol and breathing through the laryngeal mask airway were randomly allocated to three groups: (1) eight patients who received cumulative total doses of 200 microg fentanyl given in the form of two doses of 50 microg and one dose of 100 microg spaced 6 min under mechanical controlled ventilation while end-tidal carbon dioxide tension (PCO2) was maintained at 38 mmHg (fentanyl-controlled ventilation group), (2) eight patients who received cumulative total doses of 200 microg fentanyl while breathing spontaneously while end-tidal PCO2 was allowed to increase spontaneously (fentanyl-spontaneous ventilation group), and (3) six spontaneously breathing patients who were anesthetized with propofol alone (propofol group). The laryngeal mucosa of each patient was stimulated by spraying the cord with distilled water, and the evoked responses were assessed by analyzing the respiratory variables and endoscopic images. Befo...Continue Reading

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Citations

Oct 14, 2009·Lung·Kai K Lee, Surinder S Birring
Dec 1, 2008·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Uma SrivastavaImran Khan
May 10, 2005·Respiratory Physiology & Neurobiology·John Widdicombe, Vijay Singh
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Jun 24, 1998·Anesthesiology·D O Warner
May 3, 2011·Critical Care Medicine·Tarek SharsharUNKNOWN Paris-Ouest Study Group on Neurological Effect of Sedation (POSGNES)
Oct 2, 2001·The Journal of Physiology·S IsonoT Nishino
Jul 21, 2010·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Po-Jung LaiChe-Hao Hsu
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Nov 27, 2004·Pulmonary Pharmacology & Therapeutics·Giovanni Fontana, John Widdicombe
Nov 27, 2004·Pulmonary Pharmacology & Therapeutics·T NishinoT Ishikawa

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