Abstract
The striated musculature of the UES, along with the cricoid and thyroid cartilages, the hyoid bone, their ligaments, and the supra- and infrahyoid musculature form a functional unit that selectively controls the opening and closing of the esophageal inlet. At rest, upper esophageal tone acts as a barrier against both entry of air into the esophagus and regurgitation of materials coming from the proximal esophagus. However, reflexive responses of the sphincter offer no substantial protection against regurgitation of stomach contents that cause substantial esophageal distension. Although esophageal distention can experimentally induce sphincter contraction, this potential protective reflex against esophago-pharyngeal reflux has not been observed during spontaneous gastroesophageal reflux episodes. Furthermore, owing to the effects of gaseous distention, regurgitation may be more likely when acid and gaseous contents gastroesophageal reflux together. Modulation of the timing and the extent of sphincter opening during swallowing is intimately correlated with the volume and physical properties of the bolus, along with coordinated activity of the tongue, pharyngeal constrictors, and hyoid musculature, which suggests continuous sensor...Continue Reading
Citations
Feb 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arash BabaeiRavinder K Mittal
Mar 16, 2000·The American Journal of Medicine·D V Sivarao, R K Goyal
Apr 28, 2010·The Laryngoscope·Peter C BelafskyRebecca J Leonard
Mar 29, 2006·International Journal of Pediatric Otorhinolaryngology·N RommelG Veereman-Wauters
Aug 5, 2000·Otolaryngologic Clinics of North America·S O Ulualp, R J Toohill
Feb 13, 2001·Archives of Oral Biology·D E LiebermanJ B Palmer
Jul 13, 2013·European Annals of Otorhinolaryngology, Head and Neck Diseases·S MorinièreF Patat
Nov 2, 2011·Thoracic Surgery Clinics·Brandon H Tieu, John G Hunter
Mar 19, 2014·The Annals of Otology, Rhinology, and Laryngology·Corinne A JonesTimothy M McCulloch
Dec 1, 2007·Expert Review of Respiratory Medicine·Oliviero SaccoGiovanni A Rossi
Jul 29, 2003·Head & Neck·Elizabeth A VeenkerJames I Cohen
Jul 4, 2002·Current Treatment Options in Gastroenterology·Eamonn M. M. Quigley
Apr 26, 2008·Dysphagia·Eike KrauseRobert Gürkov
Apr 3, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alexios S VardouniotisGeorge A Velegrakis
Feb 2, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lilani PereraReza Shaker
Feb 24, 2001·Journal of Clinical Gastroenterology·J K DiBaiseE M Quigley
Feb 19, 2021·Physiological Measurement·Kechen ShuErvin Sejdić
Aug 26, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Francis O EdeaniReza Shaker