PMID: 8583296Nov 1, 1995Paper

Upper gastrointestinal motor abnormalities in children with active celiac disease

Journal of Pediatric Gastroenterology and Nutrition
S CucchiaraS Auricchio

Abstract

Although from the clinical point of view a GI motor disorder can be suspected in celiac disease, objective evidence for this is still lacking. We therefore conducted a study on children with active celiac disease to detect possible GI motor abnormalities in this disease. Fourteen children (age range, 1-13 years) were studied; they underwent fasting and fed manometric recordings in the gastroduodenojejunal area. Four patients were restudied after a 6-month gluten-free diet. Data were compared with those obtained in eight control children. As compared with controls, celiac disease patients showed a shorter duration of activity fronts (p < 0.01) and a significant (p < 0.01) reduction of the postprandial antral motility index; furthermore, > 90% of the patients displayed marked fasting and/or fed motor abnormalities, suggesting a neuropathic disorder. Interestingly, gut dysmotilities disappeared in the four subjects reassessed after the gluten-free diet. It is concluded that celiac disease frequently affects the motor behavior of the gut and that its effects may be reversed by appropriate diet.

Citations

May 7, 2003·Peptides·K Sjölund, R Ekman
Oct 21, 1998·Journal of Pediatric Gastroenterology and Nutrition·J A GonzálezC I Sancho
Feb 3, 2007·Current Opinion in Gastroenterology·Jason R Bratten, Michael P Jones
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Aug 16, 2008·Journal of Gastroenterology and Hepatology·Gabrio BassottiAntonio Morelli
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Mar 5, 2013·Digestive Diseases and Sciences·Gabrio BassottiEdda Battaglia
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Apr 3, 2012·Paediatrics & Child Health·Mohsin Rashid
Jun 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Tara A Altepeter, Stephen Shaffer
Jul 9, 2017·Journal of Gastroenterology and Hepatology·Vibhor V BorkarSheo Kumar
Mar 10, 2020·Gastroenterology Research and Practice·Donatella IorfidaFrancesco Valitutti

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