Upper Gastrointestinal Tract Involvement in Crohn's Disease: Frequency, Risk Factors, and Disease Course

Journal of Crohn's & Colitis
Thomas GreuterSwiss IBD Cohort Study Group

Abstract

The frequency of upper gastrointestinal [GI] tract involvement in Crohn`s disease [CD] has been reported with a large variation. Risk factors and disease course of patients with upper GI tract involvement remain largely elusive. Data on CD patients in the Swiss Inflammatory Bowel Disease Cohort were analysed. Patients with upper GI tract involvement were compared with controls. Logistic regression models for prediction of upper GI tract involvement and Cox proportional hazard models for occurrence of complications were computed. We included 1638 CD patients, of whom 107 [6.5%] presented with upper GI tract involvement at the time of diagnosis and 214 [13.1%] at any time. Prevalence of such involvement at diagnosis increased over time [5.1% for 1955-95 versus 11.3% for 2009-16]. In a multivariate logistic regression model, male sex and diagnosis between 2009 and 2016 [versus before 1995] were independent predictors for presence of upper GI tract involvement at CD diagnosis (odds ratio [OR] 1.600, p = 0.021 and OR 2.686, p < 0.001, respectively), whereas adult age was a negative predictor [OR 0.388, p = 0.001]. Patients with upper GI tract involvement showed a disease course similar to control patients (hazard ratio [HR] for any ...Continue Reading

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Citations

Dec 15, 2019·Journal of Crohn's & Colitis·Rita Vale RodriguesUNKNOWN ECCO CONFER investigators
Aug 29, 2019·Scandinavian Journal of Gastroenterology·Krzysztof DąbkowskiTeresa Starzyńska
Mar 28, 2020·United European Gastroenterology Journal
Oct 19, 2019·Inflammatory Bowel Diseases·Amandeep SinghDonald F Kirby
Sep 10, 2019·World Journal of Gastroenterology : WJG·Peter HoffmannAnnika Gauss
Nov 8, 2020·Digestive Diseases and Sciences·Juanjuan ZhangZhiming Wang
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