Upper genital tract abnormalities in the Syrian hamster as a result of in utero exposure to diethylstilbestrol. I. Uterine cystadenomatous papilloma and hypoplasia

Virchows Archiv. A, Pathological Anatomy and Histopathology
J GilloteauxA W Steggles


Prenatal exposure to diethylstilbestrol (DES) causes a significant increase in the carcinogenic response of the hamster's reproductive tract to subsequent DES treatment. Uteri from DES treated females from untreated- and DES treated mothers (C.D & D.D) have abnormal hyperplasia with characteristic finger-like structures projecting into the lumen of the uteri. Inside these papillae along with the rest of the stroma are cystic glands. We found that these glands had no openings into the uterine lumen and that they "begin" and "end" in the stroma. In addition there are two types of cells lining the cystic gland i.e., pale cells and acidophilic cells. Capillary beds surround the cystic glands. We have named these uterine structures "cystadenomatous papilloma". In addition, we found a spectrum of hyperplastic abnormalities in C.D and D.D uteri and carcinoma in situ in D.D uteri. Similar neoplasms have been described in human pathology. Ultrasound observations have demonstrated that in utero exposure to DES may result in uterine hypoplasia and because it appears to be similar to the changes seen in prenatally DES treated (D.C) hamsters, cross sectional areas of C.C (untreated control), D.C, C.D and D.D uteri were compared. Our results...Continue Reading


Jun 1, 1979·AJR. American Journal of Roentgenology·C L Rennell
Jan 1, 1979·Epidemiologic Reviews·S Shapiro, D Slone
Nov 1, 1978·American Journal of Clinical Pathology·F Tavassoli, F T Kraus
May 1, 1977·American Journal of Obstetrics and Gynecology·Arthur L HerbstR E Scully
May 1, 1977·American Journal of Obstetrics and Gynecology·R H KaufmanErvin Adam
Sep 1, 1977·Human Pathology·W R Welch, R E Scully
Sep 1, 1977·Obstetrical & Gynecological Survey·R H KaufmanErvin Adam
Jul 15, 1976·American Journal of Obstetrics and Gynecology·E C Sandberg
Feb 13, 1975·The New England Journal of Medicine·Arthur L HerbstR E Scully
May 1, 1975·American Journal of Obstetrics and Gynecology·W C Fetherston
Oct 1, 1975·British Journal of Obstetrics and Gynaecology·R RebelloH Fox
Jul 1, 1974·The Medical Clinics of North America·Kenneth Noller, C R Fish
Jul 1, 1974·Contraception·L K Kuchera
Jan 1, 1973·American Journal of Obstetrics and Gynecology·J M Morris, G Van Wagenen
Mar 1, 1972·The Journal of Pathology·G P VeloG Martinelli
Apr 15, 1971·The New England Journal of Medicine·Arthur L HerbstD C Poskanzer
Aug 12, 1971·The New England Journal of Medicine·P GreenwaldW S Burnett
Aug 1, 1968·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A W Steggles, R J King
Jul 1, 1980·Histopathology·A G Ostör, D W Fortune
Jul 1, 1980·Irish Journal of Medical Science·J F Murphy
May 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R Gottschlich, M Metzler
Jul 1, 1980·Histopathology·A J Tiltman
Mar 1, 1953·American Journal of Obstetrics and Gynecology·J H FERGUSON
Nov 1, 1953·American Journal of Obstetrics and Gynecology·W J DIECKMANNR E POTTINGER
Mar 1, 1955·American Journal of Obstetrics and Gynecology·R B SCOTT, L R WHARTON
Nov 1, 1949·Cancer·A T HERTIG, S C SOMMERS
Nov 1, 1949·Cancer·A T HERTIGH BENGLOFF
Oct 13, 1949·The New England Journal of Medicine·O W SMITH, G V SMITH

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