Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid polyneuropathy

Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
Kana TojoShu-Ichi Ikeda

Abstract

We report here two patients with amyloidogenic transthyretin (ATTR) Val30Met familial amyloid polyneuropathy (FAP) who developed numbness in both hands and were diagnosed as having bilateral carpal tunnel syndrome (CTS). In both patients systemic TTR amyloidosis consisting of polyneuropathy affecting both upper and lower limbs and/or autonomic dysfunction gradually appeared after surgery for CTS. Although CTS associated with TTR amyloidosis has been known as an initial symptom in some patients with ATTR non-Val30Met FAP and those with senile systemic amyloidosis, this is the first report of ATTR Val30Met FAP patients starting with upper limb neuropathy including CTS-like symptoms. It is also notable that both patients had no genealogical relationship with two Japanese endemic foci of this disease.

References

Jul 1, 1979·Annals of Neurology·J J KellyP J Dyck
Jun 28, 1985·Biochemical and Biophysical Research Communications·F GejyoT Shirahama
Jun 1, 1968·Archives of Neurology·S ArakiY Kuroiwa
Dec 28, 1999·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·N TachibanaS Ikeda
Nov 16, 2002·Archives of Neurology·Haruki KoikeUNKNOWN Study Group for Hereditary Neuropathy in Japan
Feb 1, 2003·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Yo-ichi TakeiShu-ichi Ikeda
Aug 22, 2003·Journal of Internal Medicine·O B SuhrP J Ranløv
Nov 11, 2003·Internal Medicine·Yo-ichi TakeiShu-ichi Ikeda
Dec 3, 2003·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Lawreen Heller ConnorsCatherine E Costello
Feb 28, 2004·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Takeshi HattoriShu-ichi Ikeda
Jun 8, 2007·Muscle & Nerve·Merrill D Benson, John C Kincaid
Jul 25, 2009·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Haruki KoikeGen Sobue

❮ Previous
Next ❯

Citations

May 18, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marco LuigettiMario Sabatelli
Sep 24, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M MatsudaS Ikeda
Feb 1, 2014·Current Neurology and Neuroscience Reports·David AdamsMichel Slama
Sep 4, 2012·Current Opinion in Neurology·David AdamsCatherine Lacroix
Jul 1, 2010·Expert Opinion on Medical Diagnostics·Haruki Koike, Gen Sobue
Aug 26, 2014·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shigeharu UchiyamaHiroyuki Kato
Jun 23, 2011·Journal of the Peripheral Nervous System : JPNS·Manuel CappellariGian Maria Fabrizi
Jun 7, 2015·Postgraduate Medical Journal·Simon DubreyJulian Gillmore
Jun 1, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·David AdamsUNKNOWN French Network for FAP
Jan 26, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Minori KodairaShu-ichi Ikeda
Oct 24, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M ThéaudinUNKNOWN French FAP Network (CORNAMYL) Study Group
Oct 5, 2019·Neurology. Clinical Practice·Chafic KaramStephen B Heitner
Apr 6, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Haruki KoikeGen Sobue
Apr 18, 2017·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Raquel SamõesTeresa Coelho
Nov 25, 2014·Expert Review of Neurotherapeutics·David AdamsMichel S Slama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloidogenesis-associated Polyneuropathy

Amyloid deposits around nerves can damage and disrupt smooth information processing between the brain and organs. Here is the latest research on amyloidosis-associated polyneuropathies.

Related Papers

Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
Haruki KoikeGen Sobue
Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
Junko FujitakeYoshihisa Tatsuoka
© 2021 Meta ULC. All rights reserved