Upregulated expression of long non-coding RNA LINC00982 regulates cell proliferation and its clinical relevance in patients with gastric cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Zheng-Hua FeiCong-Ying Xie

Abstract

Emerging evidences indicate that dysregulated long non-coding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression and might be used as diagnosis and prognosis biomarker or potential therapeutic targets. Therefore, identification of cancer-associated lncRNAs and investigation of their biological functions and molecular mechanisms are important for understanding the development and progression of cancer. In this study, we identified a novel lncRNA LINC00982, whose expression was downregulated in tumor tissues in 106 patients with gastric cancer (GC) compared with those in the adjacent normal tissues (P < 0.001). Furthermore, decreased LINC00982 expression was negatively correlated with invasion depth (P < 0.001), advanced TNM stage (P = 0.004), and regional lymph node metastasis (P = 0.005). LINC00982 levels were robust in differentiating gastric cancer tissues from controls [area under the curve (AUC) = 0.742; 95 % confidence interval (CI) = 0.678-0.800, P < 0.01]. Kaplan-Meier analysis demonstrated that decreased LINC00982 expression contributed to poor overall survival (P < 0.01) and disease-free survival (P < 0.01) of patients. A multivariate survival analysis also indicated that LINC00982 could be an indepe...Continue Reading

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Citations

Apr 23, 2016·International Journal of Environmental Research and Public Health·Lei HuLan Fan
Jun 2, 2016·Journal of Cancer Research and Clinical Oncology·Weiliang SunJunming Guo
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Huangbo GongJin Zhu
Jan 19, 2019·Oncology Letters·Dongdong QiXiong Zhang
Sep 8, 2020·Cancer Metastasis Reviews·Rachel E SextonAsfar S Azmi
Jun 22, 2017·Disease Markers·Luka BolhaDamjan Glavač
Apr 29, 2016·Briefings in Functional Genomics·Mojdeh Nasrollahzadeh-KhakianiParvaneh Nikpour
Sep 11, 2018·World Journal of Gastroenterology : WJG·Meng-Ting LinXiao-Yun Ding
May 8, 2019·Applied Microbiology and Biotechnology·Chit TamTzi Bun Ng
Jan 4, 2020·Experimental and Molecular Pathology·Soudeh Ghafouri-Fard, Mohammad Taheri
Jan 29, 2021·BioMed Research International·Weihong SunHaiping Song
Nov 26, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lei ZhengLiming Gao

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