Upregulated expression of miR-421 is associated with poor prognosis in non-small-cell lung cancer

Cancer Management and Research
Yunxia LiShuyun Li

Abstract

Non-small-cell lung cancer (NSCLC) represents the most frequent subtype of lung cancer. MicroRNAs (miRNAs) have attracted a lot of attention with regard to their clinical significance and crucial biological functions in various human cancers. This study aimed to investigate the prognostic significance of microRNA-421 (miR-421) and its correlation with tumor progression in NSCLC. Expression levels of miR-421 in both serum and tissue samples were measured by quantitative real-time polymerase chain reaction (qRT-PCR). The prognostic value of miR-421 was evaluated using Kaplan-Meier survival analysis and Cox regression assay. To explore the functional role of miR-421 during NSCLC progression, cell experiments were carried out. Expression of serum and tissue miR-421 was upregulated in the NSCLC patients compared with the normal controls (all P<0.001), and the expression showed a significant correlation between the serum samples and tissues (R=0.475, P<0.001). The increased miR-421 expression was associated with positive lymph-node metastasis and advanced TNM stage (all P<0.05). Moreover, patients with high miR-421 expression had poor overall survival compared with those with low expression (log-rank P=0.007). The overexpression of m...Continue Reading

Citations

Nov 14, 2019·Cancer Biology & Therapy·Zhaozhou RenQin Fu
Jun 25, 2020·International Journal of Molecular Sciences·Montserrat ClimentAlessandra Castaldi
May 7, 2019·Molecular Medicine Reports·Yue LiXianghong Yang
Sep 10, 2020·Cancer Management and Research·Yifan ZhouHuaqing Zhu
Mar 1, 2019·Cancers·Shang-Gin WuJin-Yuan Shih
Mar 27, 2021·BMC Bioinformatics·Bailong LiuZhengwei Li
Apr 13, 2021·Journal of Food Biochemistry·Qing-Guo CaoWen-Long Hong
Jun 3, 2021·International Journal of Molecular Sciences·Noha Mousaad ElemamNabil Sulaiman

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