Upregulated miR‑203a‑3p and its potential molecular mechanism in breast cancer: A study based on bioinformatics analyses and a comprehensive meta‑analysis

Molecular Medicine Reports
Kai-Teng CaiJin-Cai Zhong

Abstract

Breast cancer (BC) has been identified as the leading malignancy in women worldwide. However, the potential molecular mechanism of microRNA (miR)‑203a‑3p in BC remains to be elucidated. The present study evaluated the expression of miR‑203a‑3p in BC and adjacent normal tissue in several publically available datasets. The distinguishability of precursor miR‑203a and miR‑203a‑3p in BC tissue and adjacent breast tissue was assessed using receiver operating characteristic (ROC) and summarized ROC (sROC) approaches. In addition, gene ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes pathway analysis and protein‑protein interaction analysis were performed to determine the potential molecular mechanism of miR‑203a‑3p in BC. It was identified that the expression of precursor miR‑203a was markedly upregulated in 1,077 BC tissue samples compared to 104 adjacent breast tissue samples from The Cancer Genome Atlas. Additionally, an increasing trend in miR‑203a‑3p expression was observed in 756 BC tissue samples compared with 76 adjacent breast tissue samples from the University of California Santa Cruz Xena project. In addition, a comprehensive meta‑analysis suggested that the expression of miR‑203a‑3p was markedly increased...Continue Reading

Citations

Jul 8, 2015·Brain, Behavior, and Immunity·Wei SuGwenn A Garden
Nov 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yibing LiuWei Guo
Dec 25, 2015·Cellular Oncology (Dordrecht)·Mauro De SantiGiorgio Brandi
Dec 26, 2015·Biochemical and Biophysical Research Communications·Wei RenJunping Xing
Jan 20, 2016·Molecular Medicine Reports·Wei ZhouZhao-Yue Yan
Jan 29, 2016·Oncology Reports·Ai-Ling LiangYong-Jun Liu
Jun 3, 2016·Clinical Science·Hongmei Shen, Zheng Li
Jun 7, 2016·Chinese Clinical Oncology·Lei XingGuo-Sheng Ren
Jul 20, 2016·Oncology Reports·Bruno Costa GomesAntónio Sebastião Rodrigues
Aug 16, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C HennequinM A Mahé
Aug 26, 2016·Journal of Molecular Neuroscience : MN·Wenjiong HaoMaode Wang
Oct 25, 2016·Cancer Medicine·Jun-Long SongSheng-Rong Sun
Nov 2, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yanping GaoLongbang Chen
Dec 8, 2016·Anais Da Academia Brasileira De Ciências·Danylo R Costa-SilvaBenedito B DA Silva
Jul 8, 2017·Advances in Experimental Medicine and Biology·A RiemannO Thews
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 4, 2018·World Journal of Surgical Oncology·Jing ZhangJiasheng Lin
May 23, 2018·OncoTargets and Therapy·Hong-Xia HuiXiao-Wei Wang
Aug 25, 2018·Clinical Epigenetics·Daniela NasifMaría T Branham

Related Concepts

Genee-Wiedemann Syndrome
Study
Biochemical Pathway
Gene Expression Regulation, Neoplastic
Insulin-Like Growth Factor I
Graphene
Meta Analysis (Statistical Procedure)
TNM Staging System
Genome
Genes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.