Upregulation of AMWAP: a novel mechanism for HDAC inhibitors to protect against cisplatin nephrotoxicity

Kidney International
Jinhua Tang, Shougang Zhuang

Abstract

Histone deacetylases have been reported to protect against renal tubular damage in several animal models of acute renal injury, including cisplatin nephrotoxicity. However, the mechanism involved is not well defined. In this study, Ranganathan et al. identify activated microglia/macrophage WAP domain protein as the novel mediator of histone deacetylase inhibitor-mediated renal protection in a murine model of cisplatin nephrotoxicity. Activated microglia/macrophage WAP-mediated renal protection is associated with suppression of inflammation and renal epithelial cell apoptosis.

References

Nov 6, 2009·American Journal of Physiology. Renal Physiology·Guie DongZheng Dong
Apr 27, 2013·Journal of the American Society of Nephrology : JASN·Chiara Cianciolo CosentinoNeil A Hukriede
Dec 29, 2013·American Journal of Physiology. Renal Physiology·Tatiana NovitskayaMark P de Caestecker
May 9, 2014·American Journal of Physiology. Renal Physiology·Jinhua TangShougang Zhuang
Jun 26, 2014·Nature Reviews. Immunology·Michael T HenekaEicke Latz
Oct 29, 2015·Kidney International·Punithavathi RanganathanGanesan Ramesh

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Citations

Aug 20, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Chris D BartonDaniel B Hawcutt
Jun 3, 2021·Pharmaceuticals·Pía LorenLuis A Salazar

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