Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats

Journal of Neuroscience Research
Nai-Kui LiuXiao-Ming Xu

Abstract

The posttraumatic inflammatory reaction contributes to progressive tissue damage after spinal cord injury (SCI). Annexins, a family of structurally related calcium- and phospholipid-binding proteins, have potent anti-inflammatory effects by inhibiting the activity of phospholipase A(2) (PLA(2)), a key enzyme responsible for inflammation and cytotoxicity. We investigated spatiotemporal expression of annexins I, II, and V after a contusive SCI using the New York University impact device (a 10-g rod, height 12.5 mm) in adult rats. Western blot analysis revealed that annexin I expression increased at 3 days after injury, peaked at 7 days (1.75-fold above the baseline level; P < 0.01), started to decline at 14 days, and returned to the baseline level at and beyond 28 days post-injury. The expression of annexin II started to increase at 3 days, reached its maximal level at 14 days (2.73-fold; P < 0.01), remained at a high level up to 28 days, and then declined to the basal level by 56 days after injury. Annexin V expression started at 3 days, reached its maximal level at 7 days (1.61-fold; P < 0.05) and remained at this level until 56 days after injury. RT-PCR results confirmed expression of all three annexins at the mRNA level after...Continue Reading

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Citations

Feb 25, 2010·Archives of Orthopaedic and Trauma Surgery·Zhuangchen ZhuXiang Guo
Apr 25, 2006·Journal of Neurotrauma·Theo Hagg, Martin Oudega
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Jan 20, 2021·Cell Discovery·Catarina Dias, Jesper Nylandsted
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