Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis

The European Respiratory Journal
F GuddoG Turato

Abstract

The aim of the study was to investigate the expression of basic fibroblast growth factor (bFGF) and its receptor, fibroblast growth factor receptor (FGFR)-1, in the central airways of smokers with chronic bronchitis. The lobar bronchi from 17 subjects undergoing thoracotomy for solitary nodules were examined. All had a history of cigarette smoking, nine had symptoms of chronic bronchitis and airflow limitation, and eight were asymptomatic with normal lung function. Using immunohistochemical methods, bFGF and FGFR-1 expression in the total airway wall and the different airway compartments, i.e. bronchial glands, submucosal vessels and smooth muscle, was quantified. Moreover, to investigate the role of bFGF in angiogenesis, the number of submucosal vessels was quantified. Smokers with chronic bronchitis had an increased bFGF expression in the total airway wall compared with asymptomatic smokers, which was mainly due to bFGF upregulation in bronchial glands. By contrast, the expression of FGFR-1 and the number of submucosal vessels was similar in the two groups of subjects examined. In conclusion, smokers with chronic bronchitis have an increased expression of basic fibroblast growth factor in the central airways, which is mainly ...Continue Reading

Citations

Dec 12, 2012·International Journal of Molecular Sciences·Eirini NeofytouNikolaos M Siafakas
Jun 27, 2014·BioMed Research International·Prabhat SinghSrikanta Kumar Rath
Aug 28, 2007·Clinics in Chest Medicine·William Macnee
Nov 10, 2009·Respiratory Physiology & Neurobiology·Alice HuertasPaolo Palange
Jan 31, 2009·American Journal of Respiratory and Critical Care Medicine·Gordon J GaschlerMartin R Stämpfli
Oct 26, 2012·Journal of Breath Research·Laura Nunez-NaveiraCarmen Montero-Martinez
Jul 7, 2007·Physiological Reviews·Toshinori Yoshida, Rubin M Tuder
Apr 18, 2020·Frontiers in Cell and Developmental Biology·Yuanyang TanYan Yan

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