Upregulation of bikunin in tumor-infiltrating macrophages as a factor of favorable prognosis in ovarian cancer

Gynecologic Oncology
Yoshiko TanakaToshihiko Terao

Abstract

This study was carried out to clarify the localization of bikunin, a Kunitz-type protease inhibitor, and relation between expression of individual bikunin protein and ovarian cancer progression. We performed a retrospective study on the immunohistochemical expression of bikunin, urokinase-type plasminogen activator (uPA) and macrophages (CD68) in surgical specimens derived from 89 ovarian cancer patients to investigate correlations between the expression of bikunin and the clinicopathologic features and the prognosis. Furthermore, bikunin and uPA levels were measured by immunoblot analysis. Immunohistochemical staining revealed that the localization of bikunin was similar to that of CD68 for macrophages. We identified high expression of bikunin in 40 (45%) of 89 ovarian cancers. The results of Western blot analysis showed a significant correlation with immunohistochemical data. There was a significant inverse correlation between bikunin levels and uPA levels in ovarian cancer tissues. High bikunin expression was an independent predictor for disease-free survival (P = 0.040) and overall survival (P = 0.042). The 5-year survival rate of the 49 patients with low bikunin expression in ovarian cancers was 39%, whereas that of the ot...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Aug 21, 1996·Journal of the National Cancer Institute·Y TakahashiL M Ellis
Jun 17, 1999·Cell and Tissue Research·H KobayashiT Terao
Jun 16, 2001·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·I TakanamiM Karuke
Nov 29, 2002·Molecular Pathology : MP·E S Bamberger, C W Perrett
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Mika SuzukiToshihiko Terao
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iris ZemzoumNadia Harbeck
Jun 24, 2003·Biological Chemistry·Hiroshi KobayashiToshihiko Terao

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Citations

Feb 10, 2010·Journal of Translational Medicine·Qiang ZhouXiao-Shi Zhang
Jul 9, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Megan S LordJohn M Whitelock
Aug 5, 2020·Archives of Gynecology and Obstetrics·Jiang YiCheng Wenjun
Jan 26, 2020·Virchows Archiv : an International Journal of Pathology·Laura Martin de la FuenteIngrid Hedenfalk
Jan 25, 2017·Nature Reviews. Clinical Oncology·Alberto MantovaniPaola Allavena
Sep 21, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuan YinZhaohui Huang
Apr 4, 2021·Diagnostics·Ghofraan Abdulsalam AtallahNirmala Chandralega Kampan

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