Upregulation of CD20 Positive B-Cells and B-Cell Aggregates in the Tumor Infiltration Zone is Associated with Better Survival of Patients with Pancreatic Ductal Adenocarcinoma

International Journal of Molecular Sciences
Maximilian BrunnerGeorg F Weber

Abstract

Patients with pancreatic ductal adenocarcinoma (PDAC) normally have a poor long-term prognosis. However, some rare cases of long-term survivors have been reported. The tumor microenvironment, consisting of cellular and stromal components, possibly plays an important role and might influence prognosis. In this context, the role of tumor-infiltrating B-cells and its impact on the survival in patients with PDAC remains controversial. We therefore aimed to assess the prognostic value of CD20-positive B-cells and CD20-positive B-cell aggregates as well as CD138, IgM, Pax5, and Ki67 on the survival of patients with PDAC using immunohistochemistry of FFPE pancreatectomy tissue sections from patients that underwent primary surgery for pT3- and R0-pancreatic adenocarcinoma between 1995 and 2016. Patients with PDAC were matched and grouped in 16 long-term-survivors (LTS, median overall survival (OS): 96 months [range: 61-177 months]) and 16 short-term-survivors (STS, median OS: 16 months [range: 7-32 months]). CD20-positive B-cells and B-cell aggregates in the tumor infiltration zone were significantly upregulated in the LTS-group compared to the STS-group (p = 0.0499 respectively p = 0.0432). Regarding the entire patient cohort (n = 32)...Continue Reading

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Citations

Jun 11, 2020·Cancer Cell International·Huixin SongQuan Liao
Feb 20, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P A Philip
Apr 13, 2021·Frontiers in Pharmacology·Verena HofschröerAlbrecht Schwab
Sep 23, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Anna M Wu, Neeta Pandit-Taskar

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Methods Mentioned

BETA
surgical resection
pancreatectomy
xenograft

Software Mentioned

SPSS
GraphPad QuickCalcs

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