Upregulation of cholesterol synthesis after acute reduction of low density lipoprotein by apheresis in normocholesterolaemic subjects: evidence for a threshold effect

Atherosclerosis
M PfohlG R Thompson

Abstract

The influence of low density lipoproteins (LDL) in the plasma on the regulation of cholesterol biosynthesis is not clear. We studied the changes in plasma mevalonic acid (MVA) concentration and the lathosterol/cholesterol (L/C) ratio, which are well established indices of whole body cholesterol synthesis, in four normocholesterolaemic subjects after each had undergone LDL apheresis on two occasions. LDL apheresis of 75% of the calculated plasma volume reduced LDL-cholesterol by 44% to 1.5 +/- 0.2 mmol/l without changing plasma MVA levels or L/C ratios. Apheresis of 125% of the calculated plasma volume decreased plasma LDL-cholesterol by 69% to 0.9 +/- 0.2 mmol/l, with significant increases in plasma MVA and L/C ratio on the day after the procedure. These results imply that LDL-cholesterol is an integral part of the sterol regulatory pool and suggest that plasma levels cannot be lowered below 1-1.4 mmol/l in normal subjects without upregulating cholesterol biosynthesis.

References

Feb 1, 1990·Nature·J L Goldstein, M S Brown
Jul 26, 1990·The New England Journal of Medicine·E ReihnérB Angelin
Jan 1, 1988·Journal of Clinical Apheresis·R M Kellogg, J P Hester
Nov 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S YokoyamaA Yamamoto
Jul 1, 1985·The Journal of Clinical Investigation·D J McNamaraK Morrissey
Jan 1, 1984·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·P Weisweiler, P Schwandt
Sep 1, 1984·The Journal of Clinical Investigation·T S ParkerP J De Schepper
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T S ParkerE H Ahrens
Feb 1, 1994·Current Opinion in Lipidology·B R Gordon, S D Saal

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Citations

Oct 31, 1998·Biochimica Et Biophysica Acta·R P NaoumovaG R Thompson
Mar 6, 2003·Atherosclerosis·Gilbert R Thompson
Aug 7, 1998·European Journal of Clinical Investigation·M PfohlG R Thompson
Oct 19, 2001·Mayo Clinic Proceedings·A VellaT O'Brien
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·C MaugeaisM Krempf

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