Upregulation of circular RNA hsa_circ_0007534 predicts unfavorable prognosis for NSCLC and exerts oncogenic properties in vitro and in vivo

Gene
Yi QiMengna Yao

Abstract

Emerging evidence documented the key functions of circular RNAs (circRNAs) in various malignancies. Nevertheless, the research relevant to the clinical value and functions of circRNAs in non-small cell lung cancer (NSCLC) is still very limited. In this study, we performed qRT-PCR to assess the levels of hsa_circ_0007534 in NSCLC tissues and cell lines and evaluated its clinical significance using Fisher's exact test, Kaplan-Meier analysis and Cox regression analysis. Additionally, loss-of-function and gain-of-function experiments were performed to detect whether hsa_circ_0007534 could affect cell proliferation, apoptosis, metastatic properties and epithelial-mesenchymal transition (EMT) in A549 and H1299 cells. Further xenograft study was carried out to validate the in vitro data. The results indicated that hsa_circ_0007534 was up-regulated in both NSCLC tissue samples and cell lines and this up-regulation is linked to lymph node invasion and advanced TNM stage. Hsa_circ_0007534 could also function as an unfavorable prognostic indicator for the patients with NSCLC. For the part of functional assays, down-regulation of hsa_circ_0007534 suppressed cell growth, migratory and invasive capacities; facilitating cell apoptosis in A549...Continue Reading

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Citations

Mar 22, 2019·Journal of Cellular Physiology·Xin HuangZengwu Shao
Mar 3, 2020·Journal of Clinical Laboratory Analysis·Guanhua XiaoWancheng Tong
Mar 18, 2020·Wiley Interdisciplinary Reviews. RNA·Rares DrulaIoana Berindan-Neagoe
May 27, 2020·Journal of Cellular Physiology·Chao TuZhihong Li
Oct 21, 2019·Journal of Cancer Research and Clinical Oncology·Chunyan LiJunyao Li
Jun 11, 2020·Postgraduate Medical Journal·Qian YangYuanshuai Huang
Sep 20, 2019·BioMed Research International·Chengdi WangWeimin Li
Oct 17, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jason R Brown, Arul M Chinnaiyan
Jul 27, 2021·Experimental and Therapeutic Medicine·Hongguang LiangWeihua Huang

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