Abstract
The extracellular matrix (ECM) is reported to play an important role in tumorigenesis and progression. Collagen VI is an important ECM protein. In this study, we investigated the potential role of the COL6A1 gene, which encodes the α1 polypeptide of collagen VI, in the biological functions involved in the progression and outcome of clear cell renal cell carcinoma (ccRCC). A total of 288 ccRCC patients who underwent radical nephrectomy (RN) or nephron sparing nephrectomy (NSS) at Fudan University Shanghai Cancer Center (FUSCC) were enrolled. Total RNA was extracted from frozen samples obtained from the tissue bank of FUSCC and expression of COL6A1 was determined by qRT-PCR. The clinical relationship between COL6A1 expression and ccRCC prognosis was analyzed. These data were then validated in the Cancer Genome Atlas (TCGA) cohort. We also investigated the effect of COL6A1 overexpression in a xenografted tumor model in nude mice in vivo. In multivariate analysis of TCGA cohorts, COL6A1 high expression was predictive of poor prognosis in ccRCC patients' overall survival (OS) (HR: 2.588 95%CI 1.616-4.146) and disease free survival(DFS) (HR: 3.106 95%CI 1.534-6.288). In FUSCC cohorts, after adjusted for relevant factors, the COL6A1 e...Continue Reading
References
Nov 1, 1988·The Journal of Cell Biology·D R KeeneR W Glanville
Mar 30, 2001·The Journal of Biological Chemistry·F VerrecchiaA Mauviel
May 22, 2001·Stem Cells·J K ChoiA M Gewirtz
Sep 26, 2002·Neurology·H IshikawaI Nonaka
Oct 16, 2003·The Journal of Biological Chemistry·C Scott SwindleChristopher A Klug
Nov 20, 2003·Nature Genetics·William A IrwinPaolo Bonaldo
May 4, 2005·Cellular and Molecular Life Sciences : CMLS·C Jimenez-MallebreraF Muntoni
Apr 9, 2008·World Journal of Urology·Vincenzo FicarraWalter Artibani
Apr 11, 2008·The Journal of Biological Chemistry·Jamie FitzgeraldUwe Hansen
Jun 14, 2008·Genetics and Molecular Research : GMR·A FujitaM C Sogayar
Sep 8, 2009·Oncogene·B SongJ Ju
Sep 16, 2010·American Journal of Physiology. Endocrinology and Metabolism·Michael SpencerPhilip A Kern
Dec 29, 2010·Journal of Proteome Research·Kuo-Hsun ChiuPao-Chi Liao
Mar 2, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yue-Lei ChenXiaoyan Ding
Apr 5, 2011·Neuroscience·I H ChengC-Y Chao
Jul 5, 2011·Oncogene·X NiuH Yang
Jun 13, 2012·Cell Research·Mario Andres BlancoYibin Kang
Oct 9, 2012·The Journal of Clinical Investigation·Jiyoung Park, Philipp E Scherer
Jan 31, 2014·Cancer·Yi-Zhou JiangZhi-Ming Shao
Jul 1, 2014·World Journal of Gastroenterology : WJG·Anne ElsnerRobert Jaster
Nov 22, 2014·Nature Reviews. Molecular Cell Biology·Caroline BonnansZena Werb
Apr 22, 2015·Oncotarget·Yi-Ping ZhuDing-Wei Ye
Citations
Dec 17, 2017·Oncotarget·Vanessa DrendelOliver Schilling
Mar 15, 2016·Oncogene·I García-PalmeroJ I Casal
Aug 15, 2019·Experimental and Therapeutic Medicine·Zongxiang ChenJuan Du
Oct 11, 2019·PeerJ·Jieling LiShaoxiang Wang
Nov 1, 2018·Investigative Radiology·Lisa C AdamsMarcus R Makowski
Mar 20, 2019·European Radiology·Lisa C AdamsMarcus R Makowski
Feb 20, 2021·Cancer Management and Research·Qian YuHaijun Zhang