Upregulation of DLEU1 expression by epigenetic modification promotes tumorigenesis in human cancer.

Journal of Cellular Physiology
Boran PangShouping Xu

Abstract

The function of DLEU1 in human cancer is largely unknown. The Cancer Genome Atlas data were applied to identify the landscape of differential genes between tumor tissues and normal tissues, which was further validated by our cohort data and pan-cancer data including 33 cancer types with 11,060 patients. Next, DLEU1 was selected to validate the novel finding and result showed that it promoted tumorigenesis in vitro and in vivo. Mechanistically, DLEU1 promotes SRP4 expression via increasing H3K27ac enrichment to SRP4 locus epigenetically. Moreover, epigenetic modification leads to upregulation of DLEU1 expression via decreased DNA methylation and increased H3K27ac and H3K4me3 histone modification in its locus. Finally, high expression of DLEU1 correlates with worse prognosis not only in specific cancer type patients but also in patients in the pan-cancer cohort. In summary, the work broadens the function landscape of known long noncoding RNAs in human cancer and provides novel insights into their roles in tumorigenesis.

References

Jan 11, 1996·Nature·G D PennyN Brockdorff
Oct 22, 2002·Nature Structural Biology·Kon Yew KwekAlexandre Akoulitchev
Feb 26, 2009·Cell·Chris P PontingWolf Reik
May 3, 2013·Genome Research·Nasun HahW Lee Kraus
Aug 19, 2015·Frontiers in Genetics·Prashanth SuravajhalaHaja N Kadarmideen
Nov 6, 2015·Nature Medicine·Maite Huarte
Jul 26, 2017·Molecular Cancer·Shouping XuDa Pang
Oct 24, 2017·Journal of the National Cancer Institute·Ashish A DeshmukhAnna Likhacheva
Dec 22, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shouping XuDa Pang
Aug 8, 2018·Molecular Systems Biology·Benjamin D LandryMichael J Lee
Sep 29, 2018·Science·Julio A Aguirre-Ghiso
Sep 29, 2018·Science·Mingyang SongCristian Tomasetti

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Citations

Jan 24, 2020·Current Pharmaceutical Design·Chaoying SongChengfu Yuan
Feb 6, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J ChenS-B Su
Nov 11, 2020·Molecular and Cellular Biochemistry·Huiying XuXiuli Jiang
Nov 6, 2021·Journal of Gastrointestinal Cancer·Roghieh GhodratiBehzad Baradaran

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