PMID: 9161468Jan 1, 1997Paper

Upregulation of enzymatic activity by interleukin-1 in osteoarthritis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
X Chevalier

Abstract

Osteoarthritis is a slow progressive disease characterized by destruction of the articular cartilage. The degradation of extracellular matrix components is mainly mediated by a family of enzymes, the metalloproteinases (MMPs), which are active at neutral pH. Interleukin-1 (IL-1) is a small peptide, active in autocrine and paracrine fashions. In vitro IL-1 increases the production of MMPs and inhibits the synthesis of collagen type II and proteoglycans. Its role in osteoarthritis is based on several findings: IL-1 is detectable in the synovial fluid and in the cartilage matrix of osteoarthritic joints; in vivo its deleterious actions can be reproduced by intra-articular injection of recombinant IL-1; biochemical changes observed in the cartilage matrix from osteoarthritic joints resemble those induced in vitro by IL-1; finally, antagonists of IL-1 are capable in vivo of preventing or at least diminishing the degradation of cartilage matrix components in several models of experimental arthritis. Interleukin-1 appears to be a main factor mediating cartilage matrix destruction. However, its role in human osteoarthritis, although highly probable, remains to be determined.

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Citations

Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrew J WheatonRavinder Reddy
Feb 21, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joanne ArchambaultAlbert J Banes
Sep 23, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Giordano StabelliniMagda Gioia
Sep 6, 2011·Arthritis Research & Therapy·Xavier ChevalierPascal Richette
Sep 17, 2010·La Presse médicale·Xavier Chevalier
Nov 16, 2014·BMC Complementary and Alternative Medicine·Ding-Qian WuLi Ba
Mar 27, 2001·Connective Tissue Research·J F WangD A Hart
Sep 2, 2014·Arthritis Research & Therapy·Claire J GreenhillSimon A Jones
Dec 17, 2014·BMC Musculoskeletal Disorders·Aditi GuptaJoseph P Stains
Jun 13, 2003·Osteoarthritis and Cartilage·D McK CiomborB Simon
Dec 20, 2005·Biochimica Et Biophysica Acta·Joseph P Stains, Roberto Civitelli
Jan 18, 2015·Journal of Shoulder and Elbow Surgery·Danielle CasagrandeAnand M Murthi
Apr 3, 2013·Nature Reviews. Rheumatology·Xavier ChevalierPascal Richette
Jan 1, 2021·Birth Defects Research·Christopher Harshaw, Anna G Warner
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Andrea De LunaStefan Nehrer

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