Upregulation of Fas/Fas ligand in inclusion body myositis

Annals of Neurology
I M Fyhr, A Oldfors

Abstract

In inclusion body myositis, T cells invade and destroy nonnecrotic muscle fibers. The mechanism by which T cells damage muscle fibers in inflammatory myopathies is not known. In this study we have investigated the expression of Fas and Fas ligand in muscle in five patients with inclusion body myositis. Reverse transcription polymerase chain reaction showed upregulation of both Fas and Fas ligand in all inclusion body myositis patients. Immunohistochemical investigation showed expression of Fas ligand in many of the muscle infiltrating mononuclear cells. Fas was expressed both in mononuclear cells and on the surface of muscle fibers in inclusion body myositis patients and in patients with polymyositis but not in patients with Duchenne muscular dystrophy or denervation. The results indicate that the Fas/Fas ligand system may be of importance for the inflammatory reaction and T-cell-mediated muscle cell injury.

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Citations

Aug 30, 2001·Neuromuscular Disorders : NMD·M J Spencer, J G Tidball
Sep 5, 2002·Neuromuscular Disorders : NMD·D S Tews
Nov 24, 2011·Clinical & Developmental Immunology·Boel De PaepeJan L De Bleecker
Apr 14, 2000·Brain Pathology·A Bornemann, L V Anderson
Nov 7, 2000·Journal of Neuroimmunology·G VattemiG Tomelleri
Dec 28, 2007·Neuromuscular Disorders : NMD·M Needham, F L Mastaglia
Dec 19, 2001·Microscopy Research and Technique·M StangelR Gold
Nov 26, 2003·Muscle & Nerve·Dominique Figarella-BrangerJean-François Pellissier
Jun 7, 2005·Muscle & Nerve·Dominique S Tews
Aug 24, 1999·Immunology and Cell Biology·P Waring, A Müllbacher
May 2, 2002·Acta Neurologica Scandinavica·Ing-Marie FyhrA Oldfors
Jul 19, 2003·Scandinavian Journal of Immunology·K MüntzingA Oldfors
Dec 11, 1999·Current Opinion in Neurology·A Oldfors, C Lindberg

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