Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.

International Journal of Medical Sciences
Zongguo YangXiaorong Chen

Abstract

Heat shock proteins (HSPs) are overexpressed in human hepatocellular carcinoma (HCC) tissue and correlate with aggressiveness and prognosis of HCC. Using the GSE14520 microarray expression profile from Gene Expression Omnibus, we compared HSP gene expression between tumour and non-tumour tissues and correlated this with outcomes in HCC patients. We analysed 220 hepatitis B virus (HBV)-related HCC patients and 25 HSPs in this study. With the exception of HSPA4L, HSPA12A and HSPB8, members of the HSP family, including HSPH1, HSPBP1, HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPA4, HSPA5, HSPA8, HSPA9, HSPAA1, HSPAB1, HSPA14, HSPB11, HSPA13, HSP90B1 and HSPBAP1, were all overexpressed in tumour tissues (all P < 0.001). In contrast, HSPB6, HSPB7, HSPA6, HSPB2 and HSPB3 were upregulated in non-tumour tissues (all P < 0.001). Multivariate analysis showed that cirrhosis (HR = 5.282, 95% CI = 1.294-21.555, P = 0.02), Barcelona Clinic liver cancer (BCLC) staging (HR = 2.151, 95% CI = 1.682-2.750, P < 0.001), HSPA12A (HR = 1.042, 95% CI = 1.003-1.082, P = 0.033) and HSP90B1 (HR = 1.001, 95% CI = 1.000-1.001, P = 0.011) were negatively associated with survival of HBV-related HCC patients. Furthermore, advanced BCLC staging (HR = 1.797, 95% CI = 1.43...Continue Reading

Citations

Feb 13, 2016·Cell Stress & Chaperones·Jürgen Radons
Mar 10, 2016·Mutation Research·Jisheng GuoJing-Hua Yang
Jul 19, 2016·Journal of Proteomics·Jonatan Marques CamposWilliam Castro-Borges
Sep 8, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·YiRong XuXiongFeng Li
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiaoyan CaiJun Peng
Feb 2, 2018·International Journal of Molecular Sciences·Abdullah HoterHassan Y Naim
Aug 17, 2018·Bioscience Reports·Peter ShyuGuillaume Thibault
Jul 6, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Ritu KhoslaNirupma Trehanpati
Mar 11, 2020·Bioscience, Biotechnology, and Biochemistry·Da-Wei WangXiao-Tian Chang
Jan 20, 2016·World Journal of Hepatology·Ronik Khachatoorian, Samuel W French
May 27, 2020·Journal of Cellular Physiology·Masoud Nouri-VaskehBehzad Baradaran
May 19, 2019·Scientific Reports·Marta KlimczakMaciej Zylicz
Oct 28, 2019·Cells·Srikanta DashKrzysztof Moroz
May 21, 2020·DNA and Cell Biology·Hong SunBing-Li Wu
Apr 2, 2019·Experimental and Therapeutic Medicine·Kang LiuRensheng Wang
Jul 20, 2019·Medical Oncology·Ali Mohamed AlshabiChanabasayya Vastrad
Jun 27, 2019·Scientific Reports·Hamed Kharrati-KoopaeeAli Esmailizadeh
Feb 9, 2017·Frontiers in Molecular Biosciences·Pierre Goloubinoff
Apr 10, 2020·Viruses·Claudia CavaIsabella Castiglioni

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Datasets Mentioned

BETA
GSE14520

Methods Mentioned

BETA
CLIP
environmental stress

Software Mentioned

R
PASW Statistics
matchprobes
SPSS

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