Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis

Journal of Hepatology
Ying-Hsien KaoMing-Hong Tai

Abstract

Hepatoma-derived growth factor (HDGF) expression is correlated with progression of hepatocellular carcinoma. Since liver fibrosis frequently occurs before hepatoma development, this study investigated the expression profile of HDGF and its relationship with transforming growth factor-beta (TGF-beta) signaling in experimental models of hepatofibrogenesis. Liver fibrosis was induced in mice receiving bile duct ligation (BDL) or carbon tetrachloride (CCl(4)) administration. The expression levels of HDGF and other fibrosis-related markers were measured using quantitative RT-PCR, Western blotting, and enzyme-linked immunosorbent assays. Hepatic HDGF overexpression was achieved by adenovirus gene delivery. Rat hepatocytes were used to study the interplay between HDGF and TGF-beta1. In both liver fibrosis models, HDGF de novo synthesis significantly increased during the progression of fibrosis. The HDGF upregulation was observed mainly in hepatocytes and correlated with the expression of TGF-beta1 and collagen COL1A1 and COL1A2 proteins. Hepatic HDGF overexpression itself deteriorated hepatocellular structure and integrity, and aggravated the extents of BDL- and CCl(4)-induced liver fibrosis with concomitant upregulation of TGF-beta1 ...Continue Reading

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Citations

Jun 24, 2015·International Journal of Molecular Sciences·Hirayuki EnomotoShuhei Nishiguchi
Apr 20, 2014·Irish Journal of Medical Science·P WangZ Wang
Jun 9, 2016·Cell Biochemistry and Function·Guang-Yun YangJia-Hong Dong
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Aug 4, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Heba M Eltahir
Jul 18, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Shuying HeLan Bai
Jan 13, 2018·Experimental & Molecular Medicine·Ming-Shian TsaiYing-Hsien Kao
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May 24, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yueh-Hua ChungMing-Hong Tai
Oct 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E-Ming WangMing-Hong Tai
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Jun 18, 2021·World Journal of Gastroenterology : WJG·Sarah Musa HammoudehRifat Hamoudi
Sep 4, 2020·Tissue Engineering and Regenerative Medicine·Ying-Hsien KaoCheuk-Kwan Sun

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