Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance.

Mitochondrion
Natalia MendelevP Andy Li

Abstract

Overexpression of selenoprotein H (SelH) gene provides neuroprotection in neurons against UVB-induced cell death by blocking the mitochondrial-initiated apoptotic cell death pathway. This study examined the effects of SelH on mitochondrial biogenesis and mitochondrial function. The results demonstrated that overexpression of SelH gene in neuronal HT22 cells significantly increased the levels of mitochondrial biogenesis regulators, nuclear respiratory factor-1 (NRF-1), peroxisome proliferator-activated receptor-γ coactivator-1 alpha (PGC-1α) and mitochondrial transcription factor A (Tfam). Mitochondrial cytochrome c content was elevated, mass was increased and respiration was enhanced. SelH transfection ameliorated ultra violet B (UVB)-induced suppression of mitochondrial biogenesis markers and depolarization of mitochondrial membrane potential. Overexpression of SelH promotes mitochondrial biogenesis and improves mitochondrial functional performance.

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Citations

Oct 25, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R Anne StetlerJun Chen
Jul 15, 2015·Placenta·Alisha KheraAnthony V Perkins
May 23, 2015·Metallomics : Integrated Biometal Science·Bárbara Rita CardosoDominic J Hare
Mar 24, 2012·Biochimica Et Biophysica Acta·Marina V KasaikinaVadim N Gladyshev
Sep 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Andrew G CoxWolfram Goessling
Mar 17, 2017·Journal of Neuroscience Research·P Andy LiShaocai Hao
Nov 1, 2016·Molecular Neurobiology·Matthieu T CastexAnthony Falluel-Morel
May 15, 2018·Antioxidants·Evangelos ZoidisGeorgios P Danezis
Oct 23, 2014·The Journal of Biological Chemistry·Ryan T Y WuWen-Hsing Cheng
Sep 20, 2018·Biological Trace Element Research·Li ZhangWen-Hsing Cheng
May 22, 2018·Free Radical Biology & Medicine·Li ZhangWen-Hsing Cheng

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