Upregulation of hyaluronan-mediated motility receptor in hepatocellular carcinoma predicts poor survival

Oncology Letters
Xiaohu HeSongqing He

Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of cancer across the world. Hyaluronic acid (HA) has been reported to serve an important role in tumor extension, progression, migration and invasion. In addition, the receptor for HA-mediated motility (RHAMM) has been demonstrated to be overexpressed in different types of cancer. However, whether the upregulation of RHAMM contributes to hepatocarcinogenesis of HCC remains unclear. The present study examined the RHAMM expression in 187 HCC patients by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC). RHAMM expression was significantly upregulated in liver cancer tissues compared with that observed in adjacent normal liver tissues. The IHC analysis demonstrated that RHAMM was overexpressed in 18 (72.0%) of the 25 HCC tissues. Furthermore, overexpression of RHAMM was associated with tumor-node-metastasis (TNM), the presence of vascular invasion and recurrence. Notably, the present study indicated that the overexpression of RHAMM was closely associated with the shorter disease-free and overall survival, so it may be a potential independent predictor for disease-free and overall survival of HCC patients. In conclusion...Continue Reading

References

Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R FortezaM Salathe
Dec 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shlomo NedvetzkiDavid Naor
Jul 26, 2006·Carcinogenesis·Shi-Lung LinShao-Yao Ying
Jan 5, 2008·Carcinogenesis·Shi-Lung LinShao-Yao Ying
Nov 13, 2008·Cell Cycle·Samuel Godar, Robert A Weinberg
Aug 12, 2009·Development·Esteban G ContrerasJuan Larraín
Mar 26, 2011·BMC Cancer·Sumiya IshigamiShoji Natsugoe
Feb 23, 2012·Lancet·Alejandro FornerJordi Bruix
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C VerslypeUNKNOWN ESMO Guidelines Working Group
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Oct 5, 2013·Journal of Biochemistry·Paraskevi HeldinKaoru Kahata
Mar 29, 2014·Journal of Cancer Research and Clinical Oncology·Hideo ShigeishiMasaaki Takechi
Sep 18, 2015·World Journal of Gastroenterology : WJG·Yu-Cheng ZhangYa-Li Wang

❮ Previous
Next ❯

Citations

Jun 10, 2020·Cancer Cell International·Guoqing OuyangXiang Chen
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Claudia Tanja Mierke
Apr 24, 2021·Signal Transduction and Targeted Therapy·Jiacheng HuangYiting Qiao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

© 2022 Meta ULC. All rights reserved