PMID: 7522238Jul 1, 1994Paper

Upregulation of ICAM-I by Plasmodium falciparum: in vitro and in vivo studies

Journal of Clinical Pathology
W GraningerP G Kremsner

Abstract

To monitor the expression of intercellular adhesion molecule I (ICAM-I) in vitro after stimulation of human macrophages with Plasmodium falciparum antigens, as well as the plasma concentrations of soluble ICAM-I (SICAM-I) in vivo in malarial patients. Human mononuclear leucocytes were cultured and stimulated for four hours with 300 ng/ml exogenous P falciparum antigens. CD14 and CD54 (ICAM-I) expression was monitored using flow cytometry. Soluble ICAM-I (s ICAM-I) was also measured in the blood of 122 outpatients with malaria before and after treatment (Rio Branco, Acre, Brazil). ICAM-I expression increased from 15% to 375% after four hours of stimulation. When sICAM-I was analysed in the plasma of 122 patients with P falciparum or Plasmodium vivax malaria by enzyme immunoassay, significant increases were found. These were more pronounced in patients with P falciparum malaria, compared with healthy controls, and with the same patients four weeks after treatment. ICAM-I expression may also be upregulated in human macrophages by exogenous Plasmodium antigens as well as by cytokines during the acute phase of malaria. sICAM-I concentrations are downregulated after treatment, probably caused by the absence of circulating Plasmodium ...Continue Reading

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Citations

May 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·W McGuireD Kwiatkowski
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·D TaramelliP Olliaro
Jan 1, 1997·Brain Pathology·G Turner
Apr 18, 2000·Infection and Immunity·P KernN Wellinghausen
Oct 13, 2006·Malaria Journal·Ian A ClarkWilliam B Cowden

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