Abstract
To monitor the expression of intercellular adhesion molecule I (ICAM-I) in vitro after stimulation of human macrophages with Plasmodium falciparum antigens, as well as the plasma concentrations of soluble ICAM-I (SICAM-I) in vivo in malarial patients. Human mononuclear leucocytes were cultured and stimulated for four hours with 300 ng/ml exogenous P falciparum antigens. CD14 and CD54 (ICAM-I) expression was monitored using flow cytometry. Soluble ICAM-I (s ICAM-I) was also measured in the blood of 122 outpatients with malaria before and after treatment (Rio Branco, Acre, Brazil). ICAM-I expression increased from 15% to 375% after four hours of stimulation. When sICAM-I was analysed in the plasma of 122 patients with P falciparum or Plasmodium vivax malaria by enzyme immunoassay, significant increases were found. These were more pronounced in patients with P falciparum malaria, compared with healthy controls, and with the same patients four weeks after treatment. ICAM-I expression may also be upregulated in human macrophages by exogenous Plasmodium antigens as well as by cytokines during the acute phase of malaria. sICAM-I concentrations are downregulated after treatment, probably caused by the absence of circulating Plasmodium ...Continue Reading
References
Dec 1, 1992·Acta Tropica·W GraningerP G Kremsner
Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·M F AlvesC E Costa
May 1, 1992·Progress in Cardiovascular Diseases·J C Sobolski
Jan 1, 1992·Current Eye Research·E Arocker-MettingerA Kuchar
Sep 16, 1992·Biochemical and Biophysical Research Communications·R PigottA J Gearing
Nov 1, 1992·The Journal of Experimental Medicine·D E StauntonT A Springer
Aug 1, 1992·The Journal of Clinical Investigation·R HarpazM B Sztein
Mar 1, 1991·Journal of Clinical Pathology·S H GillespieK P McAdam
Jul 1, 1991·The Journal of Infectious Diseases·C F OckenhouseH K Webster
Aug 1, 1991·The Journal of Infectious Diseases·B ShohatD Mytes
May 1, 1990·The Journal of Infectious Diseases·P G KremsnerU Bienzle
Sep 7, 1989·Nature·A R BerendtK Marsh
Feb 1, 1989·The Journal of Antimicrobial Chemotherapy·P G KremsnerR M Rocha
Dec 1, 1988·The Journal of Infectious Diseases·P G KremsnerG Wiedermann
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·P Naik, A Voller
Jan 1, 1993·Transplantation·D H AdamsR Rothlein
Feb 20, 1993·Lancet·H Küster, K Degitz
Jul 1, 1993·Clinical Immunology and Immunopathology·K P MacholdW B Graninger
Jan 1, 1993·The Journal of Experimental Medicine·L Schofield, F Hackett
Jun 1, 1993·Infection and Immunity·J PradaP G Kremsner
Citations
Nov 1, 1995·Parasitology Today·I A ClarkK A Rockett
May 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·W McGuireD Kwiatkowski
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·D TaramelliP Olliaro
Jul 31, 2004·Immunology and Cell Biology·J P Dean Goldring
Jan 1, 1997·Brain Pathology·G Turner
Apr 18, 2000·Infection and Immunity·P KernN Wellinghausen
Oct 13, 2006·Malaria Journal·Ian A ClarkWilliam B Cowden
Aug 18, 2010·Malaria Journal·Christine M Cserti-GazdewichKevin C Kain
Nov 2, 2011·PloS One·Yang WuAlister G Craig
Jul 13, 2000·Neurology·H C BrownG D Turner