Upregulation of LGALS1 is associated with oral cancer metastasis

Therapeutic Advances in Medical Oncology
Ji-Min LiHong-Lin Chan

Abstract

Oral cancer metastasis is a devastating process that contributes to poor prognosis and high mortality, yet its detailed underlying mechanisms remain unclear. Here, we aimed to evaluate metastasis-specific markers in oral cancer and to provide comprehensive recognition concerning functional roles of the specific target in oral cancer metastasis. Lectin, galactoside-binding, soluble, 1 (LGALS1) was identified by secretomic analysis. LGALS1 expression of patient samples with oral cancer on the tissue microarray were examined by immunochemical (IHC) staining. Small interfering RNA (siRNA)-mediated knockdown of LGALS1 revealed the role of LGALS1 in oral cancer metastasis in vitro and in vivo. LGALS1 was observed to be upregulated in highly invasive oral cancer cells, and elevated LGALS1 expression was correlated with cancer progression and lymph node metastasis in oral cancer tissue specimens. Functionally, silencing LGALS1 resulted in suppressed cell growth, wound healing, cell migration, and cell invasion in oral cancer cells in vitro. Knockdown of LGALS1 in highly invasive oral cancer cells dramatically inhibited lung metastasis in an in vivo mouse model. Mechanistic studies suggested p38 mitogen-activated protein kinase (MAPK) p...Continue Reading

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Citations

Sep 10, 2020·International Journal of Molecular Sciences·Hsin-Yi ChenHong-Lin Chan
Feb 5, 2021·Briefings in Bioinformatics·Md Shahriare SatuMohammad Ali Moni
Jan 29, 2021·BioMed Research International·Mingyang ShenPing Wang
Nov 3, 2020·Cell Biochemistry and Function·Chin-Ho KuoHong-Lin Chan

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Methods Mentioned

BETA
electrophoresis
Transfection
enzyme-linked immunosorbent assay
ELISA
xenograft
flow cytometry

Software Mentioned

AxioVision
ImageJ
CFlow Plus
DeCyder

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