Upregulation of LINC00319 indicates a poor prognosis and promotes cell proliferation and invasion in cutaneous squamous cell carcinoma

Journal of Cellular Biochemistry
Fumin LiYongmei Liao

Abstract

Cutaneous squamous cell carcinoma (CSCC), an epidermal keratinocyte-derived skin tumor, is one of the most leading causes of cancer-associated morbidity and mortality worldwide. Long noncoding RNAs have emerged as key regulators of tumor development and progression. Recent studies have identified LINC00319, a long intergenic noncoding RNA, as an oncogene in lung cancer. However, the biological role of LINC00319 in CSCC remains largely unknown. The current study aimed to explore the role of LINC00319 in CSCC and uncover the molecular mechanisms. In current study, we found that LINC00319 was significantly upregulated in both CSCC tissues and cell lines. Besides, the χ2 test showed that increased expression of LINC00319 was associated with larger tumor size, advanced TNM stage, and lymphovascular invasion. Gain-of-function and loss-of-function approaches were applied to investigate the effects of LINC00319 on CSCC cells. Functional studies demonstrated that LINC00319 promoted CSCC cell proliferation, accelerated cell cycle progression, facilitated cell migration and invasion, and inhibited cell apoptosis. Mechanistic studies revealed that LINC00319 exerts its oncogenic functions in CSCC via miR-1207-5p-mediated regulation of cycli...Continue Reading

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Citations

Jul 10, 2020·Cancer Biotherapy & Radiopharmaceuticals·Zhe MaLin Lyu
Jul 18, 2020·Journal of Clinical Medicine·Andreea D LazarMarieta Costache
Jul 6, 2020·The Journal of Gene Medicine·Farui SunJing Ruan
Mar 19, 2020·Frontiers in Oncology·Yujia WangXian Jiang
May 29, 2020·Cellular and Molecular Life Sciences : CMLS·Minna PiipponenVeli-Matti Kähäri
Jul 22, 2019·European Journal of Pharmacology·Qiang LiHongzhe Tian
Dec 16, 2019·The American Journal of Pathology·Minna PiipponenVeli-Matti Kähäri
Aug 21, 2021·Essays in Biochemistry·Giorgio DuranteManuela Ferracin
Nov 27, 2020·Seminars in Cancer Biology·Mahendra Pratap KashyapMohammad Athar

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