Upregulation of lncRNA snoRNA host gene 6 regulates NUAK family SnF1-like kinase-1 expression by competitively binding microRNA-125b and interacting with Snail1/2 in bladder cancer

Journal of Cellular Biochemistry
Chunyang WangQiyin Chen

Abstract

Numerous studies have reported that long noncoding RNAs (lncRNAs) play critical roles in the development and progression of bladder cancer (BC). LncRNA snoRNA host gene 6 (SNHG6) is ectopically expressed in tumor tissues of patients with BC and BC cell lines. However, little is known about the molecular mechanism of SNHG6-mediated bladder urothelial carcinoma cell migration and invasion. We detected the SNHG6 levels in human BC specimens and cell lines by quantitative real-time polymerase chain reaction and Western blot, and investigated its role in BC using in vitro assays. We showed that overexpression of SNHG6 induced epithelial-mesenchymal transition (EMT) and promoted the migration and invasion capabilities of BC cells. Mechanistically, SNHG6 induced EMT of BC cells by upregulating the expression levels of Snail1/2 and regulated BC cell migration and invasion by tumor suppressive hsa-miR-125b and its target gene NUAK Family Kinase 1 (NUAK1). Furthermore, we found that SNHG6 was positively correlated with Snail1/2 expression, and negatively correlated with hsa-miR-125b expression in BC specimens. Further study showed that SNHG6 repressed hsa-miR-125b expression to upregulate Snail1/2. Conversely, hsa-miR-125b knockdown augm...Continue Reading

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Citations

Jul 14, 2020·Cancer Cell International·Haixiang ShenBen Liu
Jun 11, 2020·Cancer Cell International·Hui-Shan WangLin Miao
Jul 3, 2020·Molecular and Cellular Biochemistry·Yin ZhangYuchun Pei
Mar 31, 2021·Breast Cancer Research and Treatment·You-Quan WangWen-Ting Xu
Dec 29, 2020·Journal of Medicinal Chemistry·Muhammad FaisalSo Ha Lee

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