Abstract
Nowadays, the important roles of long non-coding RNAs (LncRNAs) in lung adenocarcinoma (LAD) is being increasingly recognized. The purpose of this study was to explore the regulatory mechanism of lncRNA ZFAS1 in LAD. The expression and function of lncRNA ZFAS1 were assessed by RT-qPCR, CCK-8, transwell and dual luciferase reporter assays. Upregulation of lncRNA ZFAS1 was found in LAD tissues and cells. Knockdown of lncRNA ZFAS1 restrained cell proliferation, migration and invasion in LAD cells. In addition, we determined that lncRNA ZFAS1 could directly bind to miR-1271-5p. MiR-1271-5p functioned as a tumor suppressor in LAD, and lncRNA ZFAS1 promoted LAD development by downregulating miR-1271-5p. Furthermore, FRS2 was a direct target of miR-1271-5p. FRS2 promoted progression of LAD by mediating lncRNA ZFAS1/miR-1271-5p axis. LncRNA ZFAS1 promotes cell proliferation, migration and invasion in LAD by downregulating miR-1271-5p or upregulating FRS2.
References
Jun 4, 2013·Journal of Hematology & Oncology·Hua ZhangYueqin Chen
May 24, 2014·Cell & Bioscience·Jun RenSteven Y Cheng
Jun 19, 2014·Genes & Development·Michael J HerrigesEdward E Morrisey
Nov 5, 2014·Molecular Cancer Research : MCR·Leo Y LuoWilliam C Hahn
Feb 17, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chong-Kin LiamJamsak Tscheikuna
Apr 16, 2016·Oncotarget·Vienna LudoviniLucio Crinò
Aug 18, 2016·Oncotarget·XiaoRong ZhongHong Zheng
Jan 10, 2018·Journal of Biochemical and Molecular Toxicology·Xiaoli SunXinwu Zhang
Sep 13, 2018·CA: a Cancer Journal for Clinicians·Freddie BrayAhmedin Jemal
Mar 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dan DongChenghai Zhao
Jun 14, 2019·Biopreservation and Biobanking·Ting LiQi Gu
Aug 14, 2019·Cancer Biomarkers : Section a of Disease Markers·Xiaoqiong WangZhiyi Cai
Aug 15, 2019·The Journal of Obstetrics and Gynaecology Research·Yanyan ChenJiefang Zhou
Oct 2, 2019·OncoTargets and Therapy·Houchao TongMeiping Shen
Oct 5, 2019·Biochemical and Biophysical Research Communications·Ziming ChengMaoxi Yuan
Nov 7, 2019·Journal of Cellular Biochemistry·Zhaolong ZengLiangqin Nie
Nov 30, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zhirong LiShujun Li
Nov 30, 2019·Frontiers in Cell and Developmental Biology·Xichun CuiGuangying Cui
Dec 13, 2019·Cancer Cell International·Zilong ZhaoWenxia Li
Dec 19, 2019·Journal of Cellular and Molecular Medicine·Jiaojiao PengShixi Liu
Jan 19, 2020·Journal of Cancer Research and Clinical Oncology·Na LiuYufeng Liu
Jan 23, 2020·Journal of Cellular and Molecular Medicine·Jiqiu HouXiaodan Li
Jan 23, 2020·Thoracic Cancer·Hao RongJintao He
May 11, 2020·Neoplasma·J H YuanB Zhang