Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients

Oncology Reports
Yoshihiko ShibayamaKen Iseki

Abstract

MicroRNAs (miRs) have been shown to negatively regulate gene expression by binding to mRNAs, and they play an important role in various physiological processes and malignancies. A previous study identified mature miR-126-3p as an onco-microRNA that is generated from the pre‑microRNA, miR-126. Although miR-126 also generates mature miR-126-5p, its function is less clear. In the present study, the relationship between miR-126-5p/3p expression levels and overall survival in 109 patients with acute myeloid leukemia (AML) who received intensive therapy were evaluated. Higher expression levels above the median value of miR-126-5p/3p were correlated with a poorer overall survival. The hazard ratio and 95% confidence intervals (95% CI) for the higher expression group relative to the lower expression group of miR-126-5p/3p were 2.098 (95% CI: 1.075-4.228) and 1.958 (95% CI: 1.001-3.927), respectively. An interaction was not observed between the hazard ratios of miR-126-5p and miR‑126-3p (p=0.73). Transfection of the mimic miR-126-5p into the AML cell line, KG-1, resulted in a decrease in the sensitivity to cytarabin and the expression level of Klotho mRNA as well as the elevation in the phosphorylation of Akt. The results of the present...Continue Reading

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Citations

Feb 10, 2016·Frontiers in Pharmacology·Neha S BhiseJatinder K Lamba
Dec 16, 2016·International Journal of Molecular Sciences·Armin ZebischHeinz Sill
Jul 5, 2017·Reproductive Sciences·Zenghui MaoLe Tang
Aug 2, 2019·Biological & Pharmaceutical Bulletin·Yoshihiko ShibayamaKen Iseki
Nov 7, 2019·Journal of Clinical Laboratory Analysis·Guopan YuDan Xu
May 18, 2016·Molecular Cancer·Chien-Hung YehChristophe Nicot
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May 28, 2019·Journal of Cellular Biochemistry·Maryam AbolghasemiDurdi Qujeq
May 18, 2020·Journal of Neuropathology and Experimental Neurology·Liang-Yi ZhuQing Chang

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Methods Mentioned

BETA
Transfection
PCR

Software Mentioned

miRanda

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