Upregulation of microRNA-133a and downregulation of connective tissue growth factor suppress cell proliferation, migration, and invasion in human glioma through the JAK/STAT signaling pathway

IUBMB Life
Peng ZhangDian-Feng Hu

Abstract

Recently, microRNA-133a (miR-133a) has been found to function in many diseases in previous studies, yet few studies have been focused on its role in glioma. This study aims to investigate the mechanism of miR-133a/CTGF on regulating the malignant phenotypes of glioma cells via the JAK/STAT signaling pathway. Sixty-five human glioma specimens were collected and 30 normal brain tissues were selected as controls. The expression of connective tissue growth factor (CTGF) and miR-133a in tissues was detected, and the relationship between their expression and the clinicopathological features as well as prognosis of glioma was analyzed. MiR-133a and CTGF expression in U87, A172, and HEB cell lines was determined. The expression of CTGF, signaling pathway-, proliferation-, migration-, invasion-, apoptosis- and epithelial-mesenchymal transition (EMT)-related factors was detected. A number of assays were used to detect cell proliferation, migration, invasion, cell cycle, apoptosis, glioma growth, and the targeting site between CTGF and miR-133a. MiR-133a was downregulated and CTGF was upregulated in human glioma tissues and cells. MiR-133a and CTGF expression was related to glioma's WHO staging and size. Downregulated miR-133a and upregul...Continue Reading

References

Mar 17, 2004·Journal of Cell Science·Jason S RawlingsDouglas A Harrison
Apr 1, 2009·Arthritis and Rheumatism·Keiichiro YamasakiMitsuo Ochi
Jul 21, 2011·Journal of the National Cancer Institute·Lincoln A EdwardsHoward A Fine
Oct 31, 2012·Journal of Leukocyte Biology·Kua-Jen BaiChien-Huang Lin
Dec 15, 2012·Cancer Genetics·McKinsey L Goodenberger, Robert B Jenkins
Apr 4, 2014·Molecular Neurobiology·Charlotte A TumilsonLisa Shaw
May 21, 2014·Neuro-oncology·Quinn T OstromJill S Barnholtz-Sloan
Jun 21, 2014·Nature Reviews. Neuroscience·Vishnu Anand CuddapahHarald Sontheimer
Jul 2, 2014·Journal of Experimental & Clinical Cancer Research : CR·Bo ZhouPing Chen
Mar 31, 2015·Experimental Eye Research·Ingeborg KlaassenReinier O Schlingemann
May 23, 2015·Nature Reviews. Cancer·Shuibin Lin, Richard I Gregory
Apr 18, 2016·Neurosurgical Review·Nancy Ann Oberheim BushMitchel S Berger
Jun 14, 2016·Journal of Photochemistry and Photobiology. B, Biology·Sandra M AyukNicolette N Houreld
Oct 7, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenbin ZhouLijiang Sun
Aug 5, 2017·ESC Heart Failure·Lars B van MiddendorpFrits W Prinzen
May 28, 2019·Frontiers in Oncology·María L Gandía-GonzálezJuan Solivera

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Citations

Jan 28, 2021·Cancers·Alexander OuAmy B Heimberger
Dec 29, 2020·Trends in Cancer·Yi-Wen ShenWei-Dong Zhang
Aug 25, 2021·Cancer Cell International·Zheng BianXiaolu Zhang

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