Upregulation of miR-155 in CD4(+) T Cells Promoted Th1 Bias in Patients With Unstable Angina

Journal of Cellular Physiology
Yanmei ChenDong Yang

Abstract

An imbalance between T helper 1 (Th1) and T helper 2 (Th2) cells has been reported to increase plaque instability in patients with unstable angina (UA). MicroRNAs play a vital role in the differentiation of CD4(+) T cells. However, the role of microRNAs in regulation of Th1/Th2 balance in UA remains unclear. In this study, we aimed to elucidate microRNA expression profiles of circulating CD4(+) T cells in UA and to explore the function of microRNAs in the Th1/Th2 balance. A total of 53 patients with UA and 31 control subjects without coronary artery disease were enrolled. Microarray analysis of the microRNA expression profiles of CD4(+) T cells revealed that miR-155 was the most significantly upregulated microRNA of the 451 differentially expressed microRNAs. The upregulation of miR-155 expression was positively correlated with the percentage of Th1 cells and interferon-gamma (IFN-γ) levels in patients with UA. In addition, overexpression of miR-155 in human circulating CD4(+) T cells promoted Th1 differentiation. Further studies identified IFN-γ receptor alpha chain (IFN-γ Rα) mRNA as a direct and functional target of miR-155. A luciferase reporter assay verified that miR-155 directly targeted IFN-γ Rα mRNA. Small-interfering ...Continue Reading

References

Sep 23, 2000·Nature·A J Lusis
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
May 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marisa BenagianoGianfranco Del Prete
Jan 22, 2005·Science·Eun Sook HwangLaurie H Glimcher
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jun 21, 2005·Journal of the American College of Cardiology·Heiko MetheElazer R Edelman
Apr 28, 2007·Science·Antony RodriguezAllan Bradley
May 18, 2007·Annual Review of Cell and Developmental Biology·Natascha Bushati, Stephen M Cohen
Oct 9, 2007·Journal of the American College of Cardiology·Giovanna LiuzzoFilippo Crea
Jun 3, 2008·Trends in Immunology·Mark A Lindsay
Aug 30, 2008·The Journal of Experimental Medicine·Xuyu ZhouJeffrey A Bluestone
Aug 30, 2008·The Journal of Experimental Medicine·Adrian ListonAlexander Y Rudensky
Sep 18, 2008·Bulletin of the World Health Organization·John R Williams
Dec 4, 2008·Journal of Lipid Research·Ziad MallatAlain Tedgui
Mar 24, 2009·Annual Review of Immunology·Elena Galkina, Klaus Ley
May 26, 2009·Immunity·Liang ZhouDan R Littman
Oct 31, 2009·European Journal of Immunology·Arnob BanerjeeSteven L Reiner
Nov 28, 2009·Journal of the American College of Cardiology·Peter LibbyUNKNOWN Leducq Transatlantic Network on Atherothrombosis
Feb 13, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Kasey C Vickers, Alan T Remaley
Mar 3, 2010·Immunology and Cell Biology·Min GuoQiutang Zeng
Apr 20, 2011·Nature Reviews. Cardiology·Charlotte LahouteAlain Tedgui
Apr 5, 2013·Immunological Reviews·James DooleyAdrian Liston
Aug 3, 2013·Nature Reviews. Immunology·Dirk Baumjohann, K Mark Ansel
Aug 21, 2013·Journal of the American Society of Nephrology : JASN·Christian F KrebsUlf Panzer

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Citations

Jun 11, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Hui MaQianming Chen
Dec 4, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Christian SchulteTanja Zeller
Jun 26, 2018·Frontiers in Physiology·Dongyan WangYan Zhao
Jan 12, 2020·Current Topics in Medicinal Chemistry·Abhishek WadhawanTeodor T Postolache
Jul 27, 2018·Disease Markers·Qiang SuLang Li

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