Upregulation of miR-24 promotes cell proliferation by targeting NAIF1 in non-small cell lung cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Guibin ZhaoJian Cui

Abstract

Recent studies have implied that aberration of miR-24 is linked to various human cancers. However, its role in non-small cell lung cancer (NSCLC) remains obscure. Here, we found that miR-24 was significantly upregulated in NSCLC tissues and patients' serum. High expression of miR-24 in patients' serum was independently correlated with a shorter overall survival of NSCLC patients. Depletion of miR-24 inhibited cell proliferation and anchorage-independent survival ability in lung cancer cell lines and reduced tumor formation ability in nude mice. Nuclear apoptosis-inducing factor 1 (NAIF1) was identified to be a functional target of miR-24 in the human lung. Next, we observed that the NAIF1 mRNA expression level in NSCLC tissues was suppressed in comparison to that in adjacent normal tissues. Restoration of NAIF1 in lung cancer cell inhibited cell proliferation and anchorage-independent survival ability, which were found to be similar with those from transfecting a miR-24 inhibitor into lung cancer cells. In conclusion, our study demonstrated that miR-24 was upregulated in NSCLC, and suppressing the expression of miR-24 inhibited tumor characteristics. MiR-24 acted as an oncomir, at least partially through regulation of its funct...Continue Reading

References

Dec 28, 2005·The International Journal of Biochemistry & Cell Biology·Bingfeng LvYaxin Lou
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Jan 19, 2007·Nature Reviews. Genetics·Kevin Chen, Nikolaus Rajewsky
Oct 5, 2007·Nature Reviews. Cancer·Lin HeGregory J Hannon
Mar 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Madhu S KumarTyler Jacks
Mar 18, 2008·Cell Cycle·Aurora Esquela-KerscherFrank J Slack
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Sep 6, 2008·PloS One·Shlomit GiladAyelet Chajut
Feb 6, 2010·Annals of Surgery·Helen M HeneghanMichael J Kerin
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
May 16, 2013·Biochemical and Biophysical Research Communications·Wen-yan ZhaoPeng Chen

❮ Previous
Next ❯

Citations

Feb 6, 2016·The Prostate·Seodhna M LynchDeclan J McKenna
Mar 14, 2016·Cancer Metastasis Reviews·Jörg HaierRichard Hummel
Oct 26, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li ChenXiao-Hui Huang
Jul 26, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Katharina HeßelbachMatjaz Humar
Mar 16, 2017·World Journal of Biological Chemistry·Stefania OlivetoStefano Biffo
Feb 13, 2018·Journal of Leukocyte Biology·Andra BaneteSameh Basta
Nov 9, 2018·Cell Biochemistry and Function·Daliang Kong, Zhe Zhang
Sep 3, 2020·Cancer Biotherapy & Radiopharmaceuticals·Dan LeiBo Zhang
May 12, 2017·Molecular Cancer·Shufang CuiXi Chen
Jun 9, 2020·Journal of Molecular Neuroscience : MN·Xuanxuan WuZengpeng Yu
Feb 9, 2021·Bioengineered·Rongqiang LiuYi Shao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.