Upregulation of Mir342 in Diet-Induced Obesity Mouse and the Hypothalamic Appetite Control.

Frontiers in Endocrinology
Dongxiao ZhangJun Wada


In obesity and type 2 diabetes, numerous genes are differentially expressed, and microRNAs are involved in transcriptional regulation of target mRNAs, but miRNAs critically involved in the appetite control are not known. Here, we identified upregulation of miR-342-3p and its host gene Evl in brain and adipose tissues in C57BL/6 mice fed with high fat-high sucrose (HFHS) chow by RNA sequencing. Mir342 (-/-) mice fed with HFHS chow were protected from obesity and diabetes. The hypothalamic arcuate nucleus neurons co-express Mir342 and EVL. The percentage of activated NPY+pSTAT3+ neurons were reduced, while POMC+pSTAT3+ neurons increased in Mir342 (-/-) mice, and they demonstrated the reduction of food intake and amelioration of metabolic phenotypes. Snap25 was identified as a major target gene of miR-342-3p and the reduced expression of Snap25 may link to functional impairment hypothalamic neurons and excess of food intake. The inhibition of miR-342-3p may be a potential candidate for miRNA-based therapy.


Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·I C BarkM C Wilson
Jul 9, 2002·Molecular and Cellular Biology·Yang Soo MoonHei Sook Sul
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A Sheila MenziesFrank B Gertler
Oct 4, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S RomeoM G Baroni
Mar 4, 2009·Nature Cell Biology·Julia WinterSven Diederichs
Sep 15, 2009·PloS One·Pooneh MokarramHassan Ashktorab
Oct 28, 2010·Genomics·Brian C Schanen, Xiaoman Li
Feb 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joo Mi YiNita Ahuja
Aug 9, 2011·Nature Biotechnology·Haydn M ProsserAllan Bradley
Jan 1, 2014·Cell Metabolism·Vasumathi KameswaranKlaus H Kaestner
Apr 25, 2014·The Journal of Clinical Endocrinology and Metabolism·Frédérik OgerPhilippe Lefebvre
Jul 27, 2014·The Journal of Antimicrobial Chemotherapy·Nicola SquillaceAndrea Gori
Mar 3, 2015·Metabolism: Clinical and Experimental·Chigusa HiguchiJun Wada
Apr 22, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Liang WangHuifang Ding
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ismael Valladolid-AcebesChristina Bark
Dec 9, 2016·Journal of Human Genetics·Naoko Hashimoto, Tomoaki Tanaka
Dec 16, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Zhenhai LiChor Sang Chim
Aug 3, 2018·Neuroscience·Muhammad IrfanChristina Bark
Oct 16, 2019·Nature Reviews. Endocrinology·Chenbo Ji, Xirong Guo
Oct 20, 2019·Journal of Molecular Biology·Lena Eliasson, Romano Regazzi
Dec 13, 2019·Nature Communications·Ohad GlaichCarmit Levy
Jun 6, 2020·Nature·Cassandra N SpracklenXueling Sim
Aug 28, 2020·Frontiers in Molecular Neuroscience·Fabio L Urbina, Stephanie L Gupton
Oct 21, 2020·Clinical Epigenetics·Min Yue ZhangChor Sang Chim
Nov 28, 2020·Nucleic Acids Research·Nikos PerdikopanisArtemis Hatzigeorgiou

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