Upregulation of monocyte tissue factor activity is significantly associated with low-grade chronic inflammation and insulin resistance in patients with metabolic syndrome

Circulation Journal : Official Journal of the Japanese Circulation Society
Akihiro NakagomiKyoichi Mizuno

Abstract

The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors closely linked to inflammation and insulin resistance (IR). Tissue factor (TF) is an initiator of the extrinsic coagulation cascade and is expressed on peripheral blood monocytes and macrophages in atherosclerotic plaques. Monocytes are the principle cells capable of TF synthesis. Therefore, TF plays an important role in both thrombosis and atherosclerosis. Elevated levels of lipopolysaccharide (LPS), a strong stimulator of TF, have been observed in patients with MetS. No study has investigated the relationship between monocyte TF activity and inflammation, and IR in MetS. Peripheral blood mononuclear cells (PBMCs) were collected from 40 normal subjects and 77 patients with MetS. Mononuclear cell TF procoagulant activity (MPCA) was measured with and without 100 pg/ml LPS stimulation using a 1-stage clotting assay and expressed as the mean +/- SD (mU TF/10(6) PBMCs). MPCA in MetS was significantly greater than in normal subjects (without LPS: 88.0+/-74.8 vs 52.6+/-9.8 mU TF/10(6) PBMCs, P<0.001; with LPS: 269.6+/-165.6 vs 158.6+/-42.8 mU TF/10(6) PBMCs, P<0.001). The LPS-stimulated log MPCA in MetS patients was significantly associated with homeostasis mod...Continue Reading

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Citations

Aug 28, 2014·Metabolic Syndrome and Related Disorders·Ishwarlal Jialal, Uthra Rajamani
Oct 6, 2011·Seminars in Immunopathology·Andrea S Rothmeier, Wolfram Ruf
Aug 6, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Sumeet MathurJohn H Boyd
Feb 24, 2012·Diabetes Care·Ishwarlal JialalSridevi Devaraj
Apr 6, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruo InoueKoichi Node
Dec 12, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Keiichi KohashiWataru Shimizu
May 1, 2014·Expert Review of Endocrinology & Metabolism·Ishwarlal JialalUthra Rajamani
Jan 29, 2021·Frontiers in Immunology·Shireen Mohammad, Christoph Thiemermann

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