Upregulation of neurodevelopmental genes during scarless healing

Annals of Plastic Surgery
Anuja K AntonyH Peter Lorenz

Abstract

Scarless fetal skin wound healing is a paradigm for ideal skin repair and is dependent on peripheral nerve function.To further explore neurogenic mechanisms influence on the scarless skin repair, fetal rats were wounded on gestational days 16 (E16; n = 24) and 18 (E18; n = 8) and wounds were harvested at 1 and 3 days after injury. Unwounded skin at identical gestational age was used for control comparison. The scarless E16 and scarring E18 wounds underwent macroarray gene expression analysis (1172 genes).During the scarless healing period, 53 (4.5%) genes had a statistically significant upregulation post-injury with at least a 2- to 3-fold change 1 day after wounding and 14 (1.2%) genes 3 days after wounding (P < 0.05). Many neurodevelopmental genes were increased during scarless repair on post-injury days 1 and 3. Neuropeptide Y Receptor type I, cJun related Transcription Factor (junD), Synaptophysin, SNAP 25, Neuronal calcium sensor 1 (NCS1), neural visine-like calcium binding protein 1 (NVP1), nerve growth factor-induced gene A (NGFI-A/EGR1), VGF8A protein, p27kip1, and members of the GABA and serotonin family each had 2- to 3-fold expression increases (P < 0.05).We speculate that fetal skin cells express neurotrophins durin...Continue Reading

References

May 15, 1992·Biochemical and Biophysical Research Communications·T KunoC Tanaka
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A HaegerstrandJ Nilsson
Apr 1, 1984·Agents and Actions·W PiotrowskiJ C Foreman
Apr 1, 1993·Physiological Reviews·M Otsuka, K Yoshioka
Mar 1, 1994·Journal of Neurobiology·A GhoshM E Greenberg
Jan 1, 1996·The Journal of Investigative Dermatology·J C AnselD Payan
Mar 18, 1996·European Journal of Pharmacology·C J WiedermannC M Kähler
Jan 1, 1995·Journal of Receptor and Signal Transduction Research·S NefP Nef
Jan 1, 1995·Progress in Cell Cycle Research·A Koff, K Polyak
Jun 26, 1999·The Journal of Investigative Dermatology·J E OlerudN W Bunnett
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
Jan 8, 2000·Plastic and Reconstructive Surgery·E J StelnickiS Mackinnon
May 30, 2001·Molecular and Cellular Endocrinology·N Takuwa, Y Takuwa
Oct 16, 2001·Burns : Journal of the International Society for Burn Injuries·V AltunE P Prens
Nov 17, 2001·The Journal of Investigative Dermatology·G J BurbachC A Armstrong
Jan 12, 2002·Plastic and Reconstructive Surgery·Steven R BeanesH Peter Lorenz
Apr 25, 2003·Plastic and Reconstructive Surgery·Catherine M DangH Peter Lorenz
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Amy S ColwellH Peter Lorenz
Jan 9, 2007·Journal of Pediatric Surgery·Bindi Naik-MathuriaOluyinka O Olutoye
Feb 26, 2008·Experimental Cell Research·Wuyi KongH Peter Lorenz
Apr 15, 2008·Journal of Pediatric Surgery·Bindi Naik-MathuriaOluyinka O Olutoye

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Citations

Jan 11, 2011·Biochemistry·Helen Y FanG Andrew Woolley
Jan 22, 2011·Dermatology Research and Practice·Latha Satish, Sandeep Kathju
Jan 18, 2013·The Keio Journal of Medicine·Kazuo KishiYoshiaki Kubota
Sep 3, 2014·International Journal of Inflammation·Lucília Pereira da SilvaEugénia Carvalho
Aug 27, 2010·Expert Opinion on Biological Therapy·Lucília da SilvaMaria Teresa Cruz
Oct 19, 2010·Hormones and Behavior·Justine SchoberDonald Pfaff
Jul 3, 2010·Immunobiology·Stephanie LeyBernhard Brüne
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Sandeep KathjuLatha Satish
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·David D LoH Peter Lorenz
Dec 23, 2015·Neural Regeneration Research·Shao-Hua LiRan Huo
Aug 12, 2016·Epigenomics·Justyna Podolak-PopinigisPaweł Sachadyn
Sep 10, 2016·Tissue Engineering. Part B, Reviews·Dorothée GirardAlexis Desmoulière
Feb 2, 2017·The Journal of Dermatological Treatment·Yeqin DaiJunhua He

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