PMID: 8590321Feb 1, 1995Paper

Upregulation of NF-kappa B-dependent gene expression mediated by the p75 tumor necrosis factor receptor

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
P RaoM V Chao

Abstract

Tumor necrosis factor (TNF-alpha) interacts with two transmembrane receptor proteins, p55TNFR and p75TNFR, which are members of a family of cell surface molecules that include the Fas antigen, CD27, CD30, CD40, OX40, a Shope fibroma viral protein, and the low-affinity p75 neurotrophin receptor. Although the p55 TNF receptor has been shown to be primarily responsible for the biologic responses of TNF-alpha, the exact involvement of the p75 TNF receptor in signaling events is unclear. Here we show that expression of a human cDNA clone for p75 in COS-1 and 3T3 cells results in the constitutive activation of an TNF-inducible NF-kappa B-containing promoter. Analysis of a number of chimeric p75 receptor cDNA constructs further suggests that this activity requires the cytoplasmic domain of the p75 receptor. These results therefore indicate that the p75 TNF receptor is capable of mediating signal transduction.

References

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Citations

Mar 25, 2000·Neurochemistry International·B D KleinK S Callahan
Oct 18, 2008·Journal of Neuroinflammation·Melissa K McCoy, Malú G Tansey
Dec 24, 1997·Leukemia & Lymphoma·K Clodi, A Younes
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R GregersenB Finsen
Dec 16, 1998·The Journal of Laboratory and Clinical Medicine·P Reverdiau-MoalicY Gruel
Feb 20, 2019·Frontiers in Neuroscience·Natalia Ortí-CasañUlrich L M Eisel
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinichi SugitaToshifumi Matsuyama

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