Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
J BrabenderPeter V Danenberg

Abstract

The Barrett's multistage process is characterized histopathologically by progression from Barrett's intestinal metaplasia to Barrett's esophagus with dysplasia and ultimately adenocarcinoma. Understanding the cellular and molecular events in this multistage process may contribute to improved diagnosis and treatment. Ornithine decarboxylase (ODC) is the first enzyme in the biosynthesis of polyamines. Elevated ODC activity has been found to be associated with progression during Barrett's esophagus, but the regulation of ODC gene expression in the development of Barrett's-associated adenocarcinoma has not been reported. The aim of this study was to assess the prevalence and timing of ODC mRNA expression in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. ODC mRNA expression levels, relative to the stably expressed internal reference gene beta-actin, were measured using a quantitative reverse transcription-polymerase chain reaction (RT-PCR) method (ABI 7700 Sequence Detector System) in 104 specimens from 19 patients with Barrett's esophagus without carcinoma and 22 patients with Barrett's-associated adenocarcinoma. The median ODC mRNA expression levels were significantly increased in Barrett's esophagus tissues compared ...Continue Reading

Citations

Oct 13, 2006·Current Opinion in Gastroenterology·Prateek Sharma, Richard E Sampliner
Aug 28, 2020·Gastroenterology Report·Erik J SniderWilliam M Grady
Apr 23, 2013·Current Gastroenterology Reports·Elizabeth Half, Nadir Arber
Oct 17, 2003·British Journal of Cancer·J BrabenderP M Schneider
Sep 15, 2007·Journal of Gastroenterology and Hepatology·Kamal E Bani-Hani, Bayan K Bani-Hani
Jul 1, 2018·Cancer Research·Aleksandra M UrbanskaMasoud Mozafari
Mar 5, 2010·Clinical Lung Cancer·Peter P GrimmingerJan Brabender

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