PMID: 16508385Mar 2, 2006Paper

Upregulation of prostaglandin E2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans

Anesthesiology
Asokumar BuvanendranKenneth J Tuman

Abstract

The central and peripheral inflammatory response to surgery may influence patient outcomes. This study examines the time course and clinical relevance of changes in prostaglandin E2 and cytokines in cerebrospinal fluid, local tissue (surgical site), and circulating blood during and after total hip replacement. Thirty osteoarthritis patients undergoing primary total hip arthroplasty with spinal anesthesia were randomly allocated to three groups (n = 10/group): placebo for 4 days before surgery and on the morning of surgery; placebo for 4 days before surgery and oral rofecoxib 50 mg on the morning of surgery; oral rofecoxib 50 mg for 4 days before surgery and the morning of surgery. Cerebrospinal fluid and plasma were collected before surgery and up to 30 h after incision for measurement of prostaglandin E2 and interleukins. When hip replacement was complete, a drain was placed in the hip wound and exudates were collected at 3 to 30 h after incision. Cerebrospinal fluid showed an initial increase in interleukin 6 and a later rise in prostaglandin E2 concentration after surgery; interleukin 1beta and tumor necrosis factor alpha were undetectable. Hip surgical site fluid evidenced an increase in prostaglandin E2, interleukin 6, int...Continue Reading

References

Aug 1, 1995·British Journal of Anaesthesia·A Dray
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R M HinsonE Shacter
Apr 11, 1996·European Journal of Pharmacology·S Oh-ishiY Hara
Feb 1, 1997·Journal of Neurochemistry·B L FiebichJ Bauer
Jul 3, 1998·European Journal of Anaesthesiology·M KristianssonM Blombäck
Feb 25, 2000·Surgery·E LinS F Lowry
Aug 2, 2000·The Journal of Physiology·T CartmellG N Luheshi
Nov 18, 2000·International Orthopaedics·D C WirtzJ M Wolff
Mar 28, 2001·The Annals of Thoracic Surgery·T KuniharaK Yasuda
Feb 28, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·David EngblomAnders Blomqvist
Aug 2, 2002·Clinical Pharmacology and Therapeutics·Asma A KhanRaymond A Dionne
Mar 26, 2003·Anesthesia and Analgesia·Raf F De JonghRené J Heylen
Apr 2, 2003·Journal of Neuroimmunology·Dale HoganMark R Opp
Nov 13, 2003·Clinical Orthopaedics and Related Research·Brett M AndresJames F Wenz
Jan 24, 2004·Anesthesiology·Jeffrey S KroinKenneth J Tuman
Sep 24, 2004·Aǧrı : Ağrı (Algoloji) Derneği'nin Yayın organıdır = The journal of the Turkish Society of Algology·Yasemin Güneş, Geylan Işik

❮ Previous
Next ❯

Citations

Jan 7, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Bertold RennerKay Brune
Dec 14, 2011·Zeitschrift für Gerontologie und Geriatrie·I TabertM Gogol
Mar 3, 2010·Surgical Endoscopy·Paolo MiccoliMichele N Minuto
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yehuda ShavitBenzion Beilin
Jan 6, 2010·Regional Anesthesia and Pain Medicine·Dag E Selander
Oct 27, 2010·Regional Anesthesia and Pain Medicine·Asokumar BuvanendranKenneth J Tuman
Sep 5, 2006·British Journal of Sports Medicine·A Buvanendran, S S Reuben
Jul 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elad NeemanShamgar Ben-Eliyahu
Jul 25, 2006·Anesthesia and Analgesia·Jeffrey S KroinKenneth J Tuman
Aug 20, 2009·Anesthesia and Analgesia·Asokumar BuvanendranMichael J Iadarola
Aug 20, 2009·Anesthesia and Analgesia·Hélène BeloeilJean-Xavier Mazoit
Nov 17, 2009·Anesthesia and Analgesia·Moritz SchererPeter K Zahn
Nov 26, 2010·Anesthesia and Analgesia·Asokumar Buvanendran, Jeffrey S Kroin
Jan 1, 2008·Journal of Pain Research·Joachim GrifkaGerhard Krammer
Dec 17, 2008·Journal of Visualized Experiments : JoVE·Brendan CarvalhoMartin S Angst
Jan 15, 2014·Journal of Neural Transmission·Rolf AnckarsäterHenrik Zetterberg
Nov 10, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Irina GrosuEmmanuel Thienpont
Dec 8, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·J A González-CorreaJ P De La Cruz
Apr 6, 2013·British Medical Bulletin·Susana VacasMervyn Maze
Feb 25, 2011·Neuro-Signals·Javaneh Tamiji, Dorota A Crawford
Sep 9, 2006·Current Opinion in Anaesthesiology·Patricia Lavand'homme
Jul 29, 2008·Current Opinion in Anaesthesiology·Alan D KayeDavid Lubarsky
Jul 17, 2009·Current Opinion in Anaesthesiology·Asokumar Buvanendran, Jeffrey S Kroin
May 22, 2010·Current Opinion in Anaesthesiology·Amrik Singh, Joseph F Antognini
Jun 12, 2010·European Journal of Anaesthesiology·Evelyne CombettesHélène Beloeil
May 2, 2014·International Journal of Nursing Practice·Yuriko MyojiYasuko Tabuchi
Oct 30, 2014·Pain Practice : the Official Journal of World Institute of Pain·Martin F BjurstromCharles A Griffis

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.