Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer

Liver International : Official Journal of the International Association for the Study of the Liver
Wei TuDean Tian

Abstract

Special AT-rich binding protein-1 (SATB1) reprograms chromatin organization and transcription profiles to promote tumour growth and metastasis. This study aimed to confirm the effects of SATB1 on the growth and metastasis of liver cancer and its specific regulation mechanism. SATB1 expression was evaluated in human hepatoma tissue, adjacent noncancerous tissue and seven kinds of liver cancer cell lines. Cell cycle, cell proliferation, apoptosis and epithelial-mesenchymal transition (EMT) was investigated after enhanced or silenced expression of SATB1. The regulatory action of SATB1 on the expression of genes that are known to regulate cell cycle progression, apoptosis and EMT and the specific apoptotic pathway on which it acts were further analysed. Nude mice that received subcutaneous implantation were used to study the effects of SATB1 on tumour growth in vivo. Our data show that the high expression of SATB1 was observed in the human hepatocellular carcinoma tissue (26/45) and liver cancer cell lines with high metastatic potential. SATB1 upregulated CDK4 and downregulated p16 (INK) (4A) to promote cell cycle progression and cell proliferation and prevented apoptosis by inhibiting the FADD-caspase-8-caspase-3 death receptor-me...Continue Reading

References

May 1, 1995·Trends in Biochemical Sciences·C J Sherr
Mar 1, 1996·The Journal of Biological Chemistry·A M ChinnaiyanV M Dixit
Dec 6, 1996·Science·C J Sherr
Oct 9, 1998·The Journal of Biological Chemistry·H R StennickeG S Salvesen
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 26, 2000·Annual Review of Genetics·S Nagata
Mar 10, 2001·Experimental Cell Research·J W Rocco, D Sidransky
May 18, 2001·Nature·G I Evan, K H Vousden
Mar 22, 2002·The Lancet Oncology·D M Parkin
Oct 11, 2002·Nature·Dag YasuiTerumi Kohwi-Shigematsu
Apr 15, 2003·Nature Genetics·Shutao CaiTerumi Kohwi-Shigematsu
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui NiePaul D Gottlieb
Mar 29, 2006·The Journal of Cell Biology·Jonathan M LeeErik W Thompson
Sep 5, 2006·Cancer Research·Jason J Christiansen, Ayyappan K Rajasekaran
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Terence K LeeSheung Tat Fan
Aug 19, 2007·The Journal of Clinical Investigation·Ulrich SteidlDaniel G Tenen
Mar 14, 2008·Nature·Hye-Jung HanTerumi Kohwi-Shigematsu
Jun 10, 2008·Nature Biotechnology·Victoria M Richon
Nov 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rajagopal N AravalliErik N K Cressman
Aug 1, 2009·Cancer Cell International·Neill PataniKefah Mokbel
Jan 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Achim WeberHenning Schulze-Bergkamen
Oct 20, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Chao ChengQiang Tong
Dec 3, 2010·Medical Hypotheses·Wen-Jian MengZong-Guang Zhou
Jan 14, 2011·Journal of Gastroenterology and Hepatology·Jorn Markus SchattenbergPeter Robert Galle

❮ Previous
Next ❯

Citations

Sep 1, 2012·Diagnostic Pathology·Björn NodinJakob Eberhard
Apr 25, 2013·World Journal of Gastroenterology : WJG·Xue-Feng FangYing Yuan
Jan 12, 2013·Digestive Diseases and Sciences·Albert J Czaja
Apr 6, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li-jun MaoYu-Xi Shan
Jul 10, 2012·Seminars in Cancer Biology·Terumi Kohwi-ShigematsuYoshinori Kohwi
Dec 31, 2015·In Vitro Cellular & Developmental Biology. Animal·Eun Ah ShinSung-hoon Kim
Dec 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Dan LuoHuo Tan
Jun 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li-Jun MaoJun-Nian Zheng
Jan 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Chang J KimNeung H Park
Nov 6, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Shailendra Kapoor
Sep 27, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Yanfeng NiuJun Liu
May 9, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Q-X CongS Jian
Apr 15, 2014·International Journal of Cancer. Journal International Du Cancer·Anja FrömbergAchim Aigner
Jan 18, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhangSong Hua
Apr 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Anna E KowalczykZbigniew Kmiec
Jan 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guangbin WangLunhao Bai
Dec 30, 2014·Carcinogenesis·Jason Brocato, Max Costa
Oct 28, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yu ZhangXiuwei Chen
Mar 31, 2018·Experimental and Therapeutic Medicine·Qiang WangJun-Qi Wang
Aug 28, 2019·International Journal of Molecular Sciences·Natalia Glatzel-PlucińskaMarzenna Podhorska-Okołów

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.