Upregulation of SEPT7 gene inhibits invasion of human glioma cells

Cancer Investigation
Song XuPeiyu Pu

Abstract

To explore the role of SEPT7 in glioma cell invasion. SEPT7 was transfected into human glioma cell lines U251 and TJ899, the invasive abilities were evaluated by transwell assay, scratch assay, and 3-D/2-D Matrigel growth. The expression of MMP2/9, MT1-MMP, integrin alpha(v)beta(3), and TIMP1/2 was detected by immunohistochemistry, immunofluorescence, and Western blot analyses. Distribution of alpha-tubulin was examined by laser scanning confocal analysis. After SEPT7 trasfection, cell invasion was inhibited, expression of MMP2/9, MT1-MMP, and integrin alpha(v)beta(3) was decreased, while TIMP1/2 was increased, and alpha-tubulin was redistributed. These results suggest that SEPT7 plays an important role in the glioma cell invasion.

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Citations

Feb 24, 2011·International Journal of Cancer. Journal International Du Cancer·Gabriel BentonIrina Arnaoutova
Mar 31, 2018·Journal of Cellular and Molecular Medicine·Xinlu WangShiwu Zhang
Jun 11, 2020·International Journal of Molecular Sciences·Lobna ElkhadragyWeiwen Long
May 10, 2020·Biotechnology Letters·Jie LiHangxing Ren
Feb 23, 2021·Molecular Therapy Oncolytics·Weihan WangZhifan Jia
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·John RedmondNicholas J Dunne

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