Upregulation of serum miR-494 predicts poor prognosis in non-small cell lung cancer patients

Cancer Biomarkers : Section a of Disease Markers
Jiajia ZhangChong Pei

Abstract

Emerging studies show that microRNAs (miRNAs) play a essential role in tumorigenesis. Deregulation of miR-494 is frequently observed in various human cancers including non-small cell lung cancer (NSCLC). However, little is known about the clinical significance of serum miR-494. The aim of this study was to investigate the diagnostic and prognostic value of serum miR-494 for NSCLC. We first compared miR-494 levels between NSCLC cell lines and lung bronchus epithelial cell line. A total of 90 NSCLC patients and 50 healthy controls were included in this study. MiR-494 levels were examined in serum samples by using real-time quantitative reverse transcription polymerase chain reactions. Association between serum miR-494 levels and the prognosis of NSCLC was further analyzed. Our results showed that miR-494 was elevated in NSCLC cell lines. Serum miR-494 levels were significantly increased in patients with NSCLC compared to healthy controls. Area under receiver operating characteristic (ROC) curve was 85.4%. In addition, serum miR-494 levels decreased remarkably when patients received effective therapy. High serummiR-494 levels were significantly associated with higher incidence of lymph node metastasis, advanced clinical stage and ...Continue Reading

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Citations

Mar 30, 2019·The Journal of International Medical Research·Wencang GaoSenquan Yu
Mar 1, 2019·Cancers·Shang-Gin WuJin-Yuan Shih
Jun 30, 2018·Journal of Hematology & Oncology·Xinwei HuangXiangyang Kong
Dec 1, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Shen ZhongJürgen Borlak

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

SigmaPlot
GraphPad
GraphPad Prism

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