Upregulation of SOX2-activated lncRNA ANRIL promotes nasopharyngeal carcinoma cell growth.

Scientific Reports
Jian-Hui WuXiong-Wen Li

Abstract

Recent molecularly targeted approaches have gained advances in nasopharyngeal carcinoma treatment. However, the estimated five-year survival rate has not met the desired degree of improvement. Here, we report that upregulation of the expression of the SOX2-activated lncRNA ANRIL is involved in nasopharyngeal carcinoma. ANRIL has been found to be upregulated in clinical nasopharyngeal carcinoma. Using genetic approaches targeting ANRIL in nasopharyngeal carcinoma cells, we found that the knockdown of ANRIL inhibits cell proliferation in vitro and in vivo. Mechanistically, SOX2 binds with ANRIL and increases its RNA level, which upregulates β-catenin signalling, resulting in enhanced nasopharyngeal carcinoma tumourigenesis. Expression levels of ANRIL are positively correlated with SOX2 and β-catenin in clinical nasopharyngeal carcinoma samples. Our findings demonstrate that the SOX2-ANRIL-β-catenin axis plays a critical role in nasopharyngeal carcinoma proliferation and provide a potential therapeutic approach for nasopharyngeal carcinoma patients.

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Citations

Sep 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying-Juan ZhengZhang-Suo Liu
Sep 29, 2020·Future Oncology·Ning LouYunbao Pan
Aug 9, 2018·Frontiers in Endocrinology·Yahui KongLaura C Alonso
Aug 23, 2020·Diagnostics·Engku Nur Syafirah E A RChan Yean Yean
Feb 7, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Hui MingCanhua Huang
Jan 14, 2021·International Journal of Molecular Sciences·Han Yeoung LeeJong Kook Park
Aug 21, 2021·Essays in Biochemistry·Giorgio DuranteManuela Ferracin
Jul 30, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Xun FangHongyan Zhou

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Methods Mentioned

BETA
xenograft
PCR
RIP
immunoprecipitation
Transfection
Assay

Software Mentioned

GraphPad
GraphPad Prism

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